Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Alberta, University of Alberta Hospital, Edmonton, AB, 1E4,33 WMC, , Canada.
J Otolaryngol Head Neck Surg. 2013 Apr 11;42(1):28. doi: 10.1186/1916-0216-42-28.
To evaluate any disparity in clinical versus pathological TNM staging in oral cavity squamous cell carcinoma (OCSCC) patients and any impact of this on survival.
Demographic, survival, staging, and pathologic data on all patients undergoing surgical treatment for OCSCC in Alberta between 1998 and 2006 was collected. Clinical and pathological TNM staging data were compared. Patients were stratified as pathologically downstaged, upstaged or unchanged.
Tertiary care centers in Alberta, Canada.
Survival differences between groups were analyzed using Kaplan-Meier and Cox regression models.
Patients with clinically early stage tumors were pathologically upstaged in 21.9% of cases and unchanged in 78.1% of cases. Patients with clinically advanced stage tumors were pathologically downstaged in 7.9% of cases and unchanged in 92.1% of cases. Univariate and multivariate estimates of disease-specific survival showed no statistically significant differences in survival when patients were either upstaged or downstaged.
Some disparity exists in clinical versus pathological staging in OCSCC, however, this does not have any significant impact on disease specific survival.
评估口腔鳞状细胞癌（OCSCC）患者临床与病理 TNM 分期的差异，以及这种差异对生存的影响。
收集了 1998 年至 2006 年期间在加拿大艾伯塔省接受手术治疗的所有 OCSCC 患者的人口统计学、生存、分期和病理数据。比较了临床和病理 TNM 分期数据。将患者分为病理降期、升期或不变。
加拿大艾伯塔省的三级保健中心。
采用 Kaplan-Meier 和 Cox 回归模型分析组间生存差异。
临床早期肿瘤患者中有 21.9%的患者病理上为升期，78.1%的患者病理上为不变期。临床晚期肿瘤患者中有 7.9%的患者病理上降期，92.1%的患者病理上不变期。单因素和多因素疾病特异性生存估计表明，升期或降期患者的生存无统计学差异。
OCSCC 患者的临床与病理分期存在一定差异，但这对疾病特异性生存没有显著影响。
