Department of Internal Medicine, En Chu Kong Hospital, Taipei County, Taiwan; School of Medicine, Fu Jen Catholic University, Taipei County, Taiwan.
Int J Cardiol. 2013 Oct 9;168(4):3309-16. doi: 10.1016/j.ijcard.2013.04.042. Epub 2013 May 7.
Perfluorinated chemicals (PFCs) have been widely used for years in a variety of products worldwide. Although epidemiological findings have shown that PFC levels are positively associated with cholesterol and uric acid levels, it is unknown whether PFCs are associated with atherosclerosis.
We recruited 664 subjects (12-30 years) from a population-based sample of adolescents and young adults based on a mass urine screening to determine the relationship between serum levels of PFCs and carotid intima-media thickness (CIMT).
The median concentrations and ranges of perfluorooctanoic acid (PFOA), perfluorooctane sulfate (PFOS), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFUA) were 3.49 (0.75-52.2) ng/mL, 8.65 (0.11-85.90) ng/mL, 0.38 (0.38-25.4) ng/mL, and 6.59 (1.50-105.7) ng/mL, respectively. After controlling for age, gender, smoking status, systolic blood pressure, body mass index, low-density lipoprotein cholesterol, triglyceride, high-sensitivity C-reactive protein, and homeostasis model assessment of insulin resistance, multiple linear regression analysis revealed that CIMT increased significantly across quartiles of PFOS (0.434 mm, 0.446 mm, 0.458 mm, 0.451 mm; P for trend <0.001). Subpopulation analysis showed the association between PFOS and CIMT was more evident and significant in females, non-smokers, subjects of age 12-19 years, BMI<24, and those with APOE genotype of E2 carrier and E3/E3.
Higher serum concentrations of PFOS were associated with an increase of carotid IMT in this cohort of adolescents and young adults. Further studies are warranted to clarify the causal relationship between PFOS and atherosclerosis.
全氟化学品（PFCs）多年来在全球各种产品中得到广泛应用。尽管流行病学研究结果表明，PFC 水平与胆固醇和尿酸水平呈正相关，但尚不清楚 PFC 是否与动脉粥样硬化有关。
我们招募了 664 名（12-30 岁）青少年和年轻成年人的基于人群的样本，进行大规模尿液筛查，以确定血清 PFC 水平与颈动脉内膜中层厚度（CIMT）之间的关系。
全氟辛酸（PFOA）、全氟辛烷磺酸（PFOS）、全氟壬酸（PFNA）和全氟癸酸（PFUA）的中位数浓度和范围分别为 3.49（0.75-52.2）ng/ml、8.65（0.11-85.90）ng/ml、0.38（0.38-25.4）ng/ml 和 6.59（1.50-105.7）ng/ml。在控制年龄、性别、吸烟状况、收缩压、体重指数、低密度脂蛋白胆固醇、甘油三酯、高敏 C 反应蛋白和胰岛素抵抗的稳态模型评估后，多元线性回归分析显示 CIMT 随 PFOS 四分位数的升高而显著增加（0.434mm、0.446mm、0.458mm、0.451mm；趋势 P<0.001）。亚群分析表明，PFOS 与 CIMT 之间的关联在女性、非吸烟者、12-19 岁年龄组、BMI<24 和 APOE 基因型为 E2 携带者和 E3/E3 的人群中更为明显和显著。
在该队列的青少年和年轻成年人中，较高的血清 PFOS 浓度与颈动脉 IMT 的增加有关。需要进一步的研究来阐明 PFOS 与动脉粥样硬化之间的因果关系。
