State Key Lab of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China.
State Key Lab of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Chemosphere. 2014 Sep;110:104-10. doi: 10.1016/j.chemosphere.2014.02.020. Epub 2014 Mar 13.
133 Serum samples collected from Henan donors aged from 0 to 88years were analyzed for 12 perfluorinated compounds (PFCs). Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) accounted for 69.19% of the total PFCs in serum samples, with a median concentration of 1.43 and 1.47ngmL(-)(1), respectively. Other PFCs were detected at much lower concentrations, with median concentrations ranging from 0.03 to 0.37ngmL(-)(1). PFOA and PFOS were positively correlated (r=0.219) in serum samples, indicating that they may have common exposure pathways. For all donors (0-88years), significant increases in PFOA (r=0.239, p<0.01), perfluorononanoic acid (PFNA) (r=0.185, p<0.05) and PFOS (r=0.175, p<0.05) concentrations over age were found. Median concentrations of PFOA, PFNA, perfluorodecanoic acid (PFDA), and PFOS were higher in males than in females. Higher PFOA concentrations were found in urban populations than in rural populations. Since PFCs exposure in general population is prevalent, further studies are needed to explore its possible impacts on epidemiological factors.
133 份来自河南省 0 至 88 岁捐赠者的血清样本用于分析 12 种全氟化合物 (PFCs)。全氟辛酸 (PFOA) 和全氟辛烷磺酸 (PFOS) 在血清样本中占总 PFCs 的 69.19%，中位数浓度分别为 1.43 和 1.47ngmL(-)(1)。其他 PFCs 的浓度要低得多，中位数浓度范围为 0.03 至 0.37ngmL(-)(1)。血清样本中 PFOA 和 PFOS 呈正相关 (r=0.219)，表明它们可能具有共同的暴露途径。对于所有捐赠者 (0-88 岁)，PFOA (r=0.239，p<0.01)、全氟壬酸 (PFNA) (r=0.185，p<0.05) 和 PFOS (r=0.175，p<0.05) 浓度随年龄增长呈显著增加趋势。血清样本中 PFOA、PFNA、全氟癸酸 (PFDA) 和 PFOS 的中位数浓度均高于女性。与农村人群相比，城市人群的 PFOA 浓度更高。由于一般人群中 PFCs 的暴露普遍存在，因此需要进一步研究以探讨其对流行病学因素的可能影响。
