Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94143, USA.
Neuron. 2013 May 8;78(3):433-9. doi: 10.1016/j.neuron.2013.02.030.
The cell-autonomous role of synaptic transmission in the regulation of neuronal structural and electrical properties is unclear. We have now employed a genetic approach to eliminate glutamatergic synaptic transmission onto individual CA1 pyramidal neurons in a mosaic fashion in vivo. Surprisingly, while electrical properties are profoundly affected in these neurons, as well as inhibitory synaptic transmission, we found little perturbation of neuronal morphology, demonstrating a functional segregation of excitatory synaptic transmission from neuronal morphological development.
突触传递在调节神经元结构和电生理特性方面的细胞自主性作用尚不清楚。我们现在采用了一种遗传方法，以镶嵌方式在体内消除单个 CA1 锥体神经元上的谷氨酸能突触传递。令人惊讶的是，尽管这些神经元的电生理特性以及抑制性突触传递受到了深刻影响，但神经元形态的改变却很小，这表明兴奋性突触传递与神经元形态发育是功能分离的。
