稳态突触可塑性：从单个突触到神经回路。
Homeostatic synaptic plasticity: from single synapses to neural circuits.
机构信息
MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, University College London, Gower Street, London WC1E 6BT, UK.
出版信息
Curr Opin Neurobiol. 2012 Jun;22(3):516-21. doi: 10.1016/j.conb.2011.09.006. Epub 2011 Oct 7.
Abstract
Homeostatic synaptic plasticity remains an enigmatic form of synaptic plasticity. Increasing interest on the topic has fuelled a surge of recent studies that have identified key molecular players and the signaling pathways involved. However, the new findings also highlight our lack of knowledge concerning some of the basic properties of homeostatic synaptic plasticity. In this review we address how homeostatic mechanisms balance synaptic strengths between the presynaptic and the postsynaptic terminals and across synapses that share the same postsynaptic neuron.
摘要
稳态突触可塑性仍然是一种神秘的突触可塑性形式。对这一主题的日益关注激发了最近大量研究的涌现，这些研究已经确定了涉及的关键分子参与者和信号通路。然而，新的发现也突出了我们对稳态突触可塑性的一些基本特性缺乏了解。在这篇综述中，我们探讨了稳态机制如何平衡突触前和突触后终端之间以及共享相同突触后神经元的突触之间的突触强度。
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