Instituto de Biología y Genética Molecular, Universidad de Valladolid y Consejo Superior de Investigaciones Científicas, Valladolid, Spain.
Semin Cell Dev Biol. 2013 May;24(5):507-13. doi: 10.1016/j.semcdb.2013.04.004. Epub 2013 May 9.
Cell cycle exit and acquirement of a postmitotic state is essential for the proper development of organs. In the present review, we examine the role of the cell cycle control in the sensory epithelia of the mammalian inner ear. We describe the roles of the core cell cycle regulators in the proliferation of prosensory cells and in the initiation and maintenance of terminal mitosis of the sensory epithelia. We also discuss how other intracellular signalling may influence the cell cycle. Finally, we address the question of whether manipulations of the cell cycle may have the potential to create replacement cells for the damaged inner sensory epithelia.
细胞周期退出和获得有丝分裂后状态对于器官的正常发育至关重要。在本综述中，我们研究了细胞周期调控在哺乳动物内耳感觉上皮中的作用。我们描述了核心细胞周期调节剂在前感觉细胞增殖以及感觉上皮的起始和维持终末有丝分裂中的作用。我们还讨论了其他细胞内信号如何影响细胞周期。最后，我们探讨了细胞周期的操纵是否有可能为受损的内耳感觉上皮创造替代细胞的问题。
