大鼠中Es-4基因座的一个新变体。

A new variant of the Es-4 locus in the rat.

作者信息

Katoh H, Utsu S, Wakana S, Li Q F

机构信息

Department of Genetics, Central Institute for Experimental Animals, Kawasaki, Japan.

出版信息

Lab Anim. 1990 Apr;24(2):176-9. doi: 10.1258/002367790780890103.

DOI:10.1258/002367790780890103

PMID:2366516

Abstract

A new variant of kidney esterase in the DK/Nac rat strain is reported. The new esterase was tentatively named ES-4C determined by a third allele of the Es-4 locus of Linkage Group V (LGV). Strain distribution was surveyed using 17 inbred strains, but no strain except for the DK/Nac strain possessed the ES-4C type. Although we surveyed outbred stocks (Jcl: Wistar and Jcl: SD) we could not find rats carrying the ES-4C type. Genetic analysis of the ES-4C type was carried out using mating experiments between DK/Nac and BUF/Nac (ES-4B). The results indicated that the new variant was controlled by the Es-4 locus and it was named the Es-4c allele.

摘要

据报道，在DK/Nac大鼠品系中发现了一种新型肾脏酯酶。这种新型酯酶由第五连锁群（LGV）的Es-4基因座的第三个等位基因暂时命名为ES-4C。使用17个近交系对品系分布进行了调查，但除DK/Nac品系外，没有其他品系具有ES-4C类型。尽管我们对远交种群（Jcl:Wistar和Jcl:SD）进行了调查，但未发现携带ES-4C类型的大鼠。通过DK/Nac和BUF/Nac（ES-4B）之间的交配实验对ES-4C类型进行了遗传分析。结果表明，这种新变体由Es-4基因座控制，并将其命名为Es-4c等位基因。