实验小鼠中的酯酶-6（Es-6）：激素影响的表达以及与8号染色体上少趾畸形（Os）、酯酶-1（Es-1）和酯酶-2（Es-2）的连锁关系。

Esterase-6 (Es-6) in laboratory mice: hormone-influenced expression and linkage relationship to oligosyndactylism (Os), esterase-1 (Es-1), and esterase-2 (Es-2) in chromosome 8.

作者信息

Womack J E

出版信息

Biochem Genet. 1975 Jun;13(5-6):311-22. doi: 10.1007/BF00485816.

Abstract

Allelic differences at an esterase locus designated Es-6 exist between mouse strain C57 BL/6J and a laboratory stock of M.m. molossinus. Strain C57BL/6J has been assigned the allele Es-6a and M. m. molossinus the alternate allele Es-6b. Kidney expression of the electrophoretic esterase band controlled by the Es-6 locus is sex influenced, with increased activity apparently induced by testosterone. A four-point test cross established the gene order Os-Es-1-Es-6-Es-2 within a 10-cM segment on chromosome 8.

摘要

在小鼠品系C57 BL/6J和小家鼠日本亚种的一个实验室种群之间，在一个名为Es-6的酯酶基因座上存在等位基因差异。C57BL/6J品系被指定为等位基因Es-6a，而小家鼠日本亚种则为另一个等位基因Es-6b。由Es-6基因座控制的电泳酯酶带在肾脏中的表达受性别影响，睾酮显然会诱导其活性增加。四点测交确定了8号染色体上一个10厘摩区段内的基因顺序为Os-Es-1-Es-6-Es-2。