Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Key Laboratory of Endocrine Tumor, Shanghai Institute of Endocrinology and Metabolism, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui-Jin 2nd Road, Shanghai 200025, China.
J Hepatol. 2013 Sep;59(3):557-62. doi: 10.1016/j.jhep.2013.04.030. Epub 2013 May 9.
BACKGROUND & AIMS: Obesity is closely related to non-alcoholic fatty liver disease (NAFLD), which has become an important public health problem because of its high prevalence and association with metabolic syndromes. Irisin was recently identified as a novel peptide to improve obesity and glucose homeostasis, and considered to be therapeutic for human metabolic diseases. The aim of this study was to examine the association of serum irisin concentration and liver triglyceride contents in obese Chinese adults.
Serum irisin levels were measured and liver fat contents determined by (1)H MRS in 296 obese adults. Anthropometric parameters and blood biochemical indexes including liver enzymes, glucose, and lipid profiles were detected. The liver triglyceride contents of subjects were measured by (1)H MRS. The protein levels of irisin were determined by quantitative ELISA.
We found that serum irisin levels were reduced in obese adults with NAFLD. By dividing the distribution of intrahepatic triglyceride (IHTG) contents into quartiles, serum irisin levels were reduced gradually with the increase of IHTG contents (p<0.01). Higher serum irisin levels were associated with preferable TG levels. Serum ALT and AST concentrations were inversely correlated with serum irisin levels. Multivariate linear regression analysis demonstrated that serum irisin levels were independently associated with liver fat (p<0.01). By logistic regression analysis, the odds ratio for higher IHTG contents was reduced by 12.4% per 1 SD increase in serum irisin concentrations after adjustment for multivariate metabolic factors [OR (95% CI); 0.876 (0.777-0.987)].
These results demonstrated that serum irisin concentrations were inversely associated with the triglyceride contents in the liver and liver enzymes in obese Chinese adults.
肥胖与非酒精性脂肪性肝病（NAFLD）密切相关，由于其高患病率和与代谢综合征的关联，已成为一个重要的公共卫生问题。鸢尾素最近被鉴定为一种改善肥胖和葡萄糖稳态的新型肽，被认为对人类代谢疾病具有治疗作用。本研究旨在探讨肥胖中国成年人血清鸢尾素浓度与肝甘油三酯含量的关系。
对 296 例肥胖成年人进行（1）H MRS 检测血清鸢尾素水平和肝脂肪含量。检测人体测量参数和血液生化指标，包括肝酶、血糖和血脂谱。用（1）H MRS 测量受试者的肝甘油三酯含量。用定量 ELISA 法测定鸢尾素的蛋白水平。
我们发现，NAFLD 肥胖患者的血清鸢尾素水平降低。通过将肝内甘油三酯（IHTG）含量的分布分为四等份，随着 IHTG 含量的增加，血清鸢尾素水平逐渐降低（p<0.01）。较高的血清鸢尾素水平与较好的 TG 水平相关。血清 ALT 和 AST 浓度与血清鸢尾素水平呈负相关。多元线性回归分析表明，血清鸢尾素水平与肝脂肪独立相关（p<0.01）。通过逻辑回归分析，在校正多元代谢因素后，血清鸢尾素浓度每增加 1 SD，IHTG 含量升高的几率降低 12.4%[比值比（95%CI）；0.876（0.777-0.987）]。
这些结果表明，血清鸢尾素浓度与肥胖中国成年人肝脏甘油三酯含量和肝酶呈负相关。
