Department of Ophthalmology, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
Cornea. 2013 Aug;32(8):1126-30. doi: 10.1097/ICO.0b013e318292b7a2.
To investigate the relation between the severity of conjunctivochalasis and the axial length (AL) of the eyeball.
A prospective nonrandomized study was performed on 165 patients aged 51 to 88 years. The age, gender, medical history, ocular history, grade and other parameters of inferior conjunctivochalasis (classified as nasal, middle, and temporal), and AL were determined in all patients. Patients were divided into a short AL group (≤ 22.0 mm), a medium AL group (>22.0 to ≤ 24.0 mm), and a long AL group (>24.0 mm).
The short AL group tended to have higher grades of temporal and nasal conjunctivochalasis compared with the medium and long AL groups. Multivariate logistic regression analysis showed that the total conjunctivochalasis score (the sum of the scores for the temporal, middle, and nasal regions) was significantly associated with the age [odds ratio (OR) = 1.32, P = 0.001] and the AL (OR = 0.81, P = 0.029). In addition, the AL was independently associated with the grade of conjunctivochalasis after adjustment for age (OR = 0.80, P = 0.020).
This was the first assessment of the relationship between the AL and the grade of conjunctivochalasis. Our findings suggest that the severity of conjunctivochalasis is dependent on the AL, with a short AL contributing to the pathogenesis of conjunctivochalasis.
研究眼轴长度（AL）与结膜松弛症严重程度之间的关系。
对 165 名年龄在 51 至 88 岁的患者进行前瞻性非随机研究。所有患者均确定了年龄、性别、病史、眼部病史、下结膜松弛症（分为鼻侧、中间和颞侧）的严重程度和其他参数以及 AL。患者分为短眼轴组（≤22.0mm）、中眼轴组（>22.0 至≤24.0mm）和长眼轴组（>24.0mm）。
与中、长眼轴组相比，短眼轴组的颞侧和鼻侧结膜松弛症的严重程度更高。多变量逻辑回归分析显示，总结膜松弛症评分（颞部、中部和鼻部得分总和）与年龄[比值比（OR）=1.32，P=0.001]和 AL（OR=0.81，P=0.029）显著相关。此外，在调整年龄后，AL 与结膜松弛症的严重程度独立相关（OR=0.80，P=0.020）。
这是首次评估 AL 与结膜松弛症严重程度之间的关系。我们的研究结果表明，结膜松弛症的严重程度取决于 AL，短 AL 有助于结膜松弛症的发病机制。
