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利多卡因预防性扁桃体周围浸润用于缓解双极成人扁桃体切除术后疼痛:一项随机、双盲临床研究。

Preemptive peritonsillar infiltration with lidocaine for relief of bipolar adult post-tonsillectomy pain: a randomized, double-blinded clinical study.

机构信息

Department of Otolaryngology, Shandong Provincial Hospital, Shandong University, 16866, Jingshi Road, Jinan, Shandong, China,

出版信息

Eur Arch Otorhinolaryngol. 2013 Nov;270(12):3195-8. doi: 10.1007/s00405-013-2549-2. Epub 2013 May 11.

DOI:10.1007/s00405-013-2549-2
PMID:23665671
Abstract

There are discordant results in the studies of the peritonsillar infiltration in adults undergoing the tonsillectomy. The study is to compare the effect of the preemptive peritonsillar infiltration with lidocaine in bipolar tonsillectomy in adult. 172 adult patients were randomly located into five groups before tonsillectomy: group 0: without the peritonsillar infiltration, group 1: for 3 ml normal saline with 1:200,000 epinephrine per tonsil, group 2: for 3 ml 1 %lidocaine with 1:200,000 epinephrine per tonsil, group 3: for 8 ml normal saline with 1:200,000 epinephrine per tonsil, group 4: for 8 ml lidocaine with 1:200,000 epinephrine per tonsil. The post-operative pain in the following 7 days was assessed by visual analog scale. Operation time and post-operative bleeding were also recorded. No significant differences were found between operative times, post-tonsillectomy hemorrhage between the five groups. The differences between pain scores of the group 0, group 1 and group 2 were not statistically significant (P > 0.05). The differences between pain scores of group 3, group 4 against group 0, group 1, group 2 were statistically significant (P < 0.05). We found the volume of peritonsillar infiltration might contribute to the relief of pain of the bipolar post-tonsillectomy.

摘要

在接受扁桃体切除术的成年人中,扁桃体周围浸润的研究结果存在差异。本研究旨在比较预防性扁桃体周围利多卡因浸润对成人双极扁桃体切除术的影响。172 例成年患者在扁桃体切除术前随机分为五组:0 组:无扁桃体周围浸润;1 组:每侧扁桃体注射 3 ml 生理盐水加 1:200,000 肾上腺素;2 组:每侧扁桃体注射 3 ml 1%利多卡因加 1:200,000 肾上腺素;3 组:每侧扁桃体注射 8 ml 生理盐水加 1:200,000 肾上腺素;4 组:每侧扁桃体注射 8 ml 利多卡因加 1:200,000 肾上腺素。术后 7 天采用视觉模拟评分法评估术后疼痛。记录手术时间和术后出血情况。五组间手术时间、扁桃体切除术后出血无统计学差异(P > 0.05)。0 组、1 组和 2 组间疼痛评分差异无统计学意义(P > 0.05)。3 组、4 组与 0 组、1 组、2 组比较疼痛评分差异有统计学意义(P < 0.05)。我们发现扁桃体周围浸润的体积可能有助于缓解双极扁桃体切除术后的疼痛。

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本文引用的文献

1
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Int J Pediatr Otorhinolaryngol. 2012 Dec;76(12):1831-4. doi: 10.1016/j.ijporl.2012.09.011. Epub 2012 Sep 27.
2
Six years of evidence-based adult dissection tonsillectomy with ultrasonic scalpel, bipolar electrocautery, bipolar radiofrequency or 'cold steel' dissection.六年基于证据的成人扁桃体切除术,采用超声刀、双极电凝、双极射频或“冷钢”进行剥离。
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Comparison of peritonsillar infiltration effects of ketamine and tramadol on post tonsillectomy pain: a double-blinded randomized placebo-controlled clinical trial.
氯胺酮和曲马多对扁桃体切除术后疼痛的扁桃体周围浸润效果比较:一项双盲随机安慰剂对照临床试验。
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Acta Otolaryngol. 2012 Jun;132 Suppl 1:S130-3. doi: 10.3109/00016489.2012.659752. Epub 2012 Mar 4.
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Eur Arch Otorhinolaryngol. 2012 May;269(5):1533-6. doi: 10.1007/s00405-011-1872-8. Epub 2011 Dec 13.
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