Bayram Ali, Doğan Murat, Cihan Celalettin, Karataş Duran, Gökahmetoğlu Günhan, Özcan Ibrahim
*Department of ENT, Kayseri Training and Research Hospital †Department of ENT, Kayseri Special Ibni Sina Hospital ‡Department of ENT, Special Versa Hospital, Nevşehir §Department of Anesthesiology, Kayseri Training and Research Hospital, Kayseri, Turkey.
J Craniofac Surg. 2015 Oct;26(7):e651-3. doi: 10.1097/SCS.0000000000001975.
The aim of the study is to evaluate the efficacy of peritonsillar infiltration of a levobupivacaine hydrochloride and dexamethasone combination for post-tonsillectomy pain in adult patients.
A total of 40 patients were included in this double-blind, randomized, and placebo-controlled study. The patients were equally randomized into 2 groups by means of sealed envelopes. The study group (SG) received peritonsillar levobupivacaine hydrochloride and dexamethasone infiltration and the control group (CG) received peritonsillar saline infiltration. Pain scores at the second, fourth, eighth, 12th, 16th, and 24th hours and the second to seventh days after operation were recorded by the patients in each group using a visual analog scale. Duration of surgery and the total amount of blood loss during the surgery were also recorded for each patient.
All pain scores in the SG were lower than those in the CG; however, the difference was significant at the second, 12th, and 16th hours, and the second and third day (P < 0.05). Postoperative morbidity parameters, including otalgia, nausea, vomiting, fever, halitosis, and bleeding were similar between the 2 groups. Total amount of analgesic consumption in the SG was significantly lower than in the CG on each day of the week after tonsillectomy.
Peritonsillar infiltration of a levobupivacaine hydrochloride and dexamethasone combination may provide pain reduction and decrease analgesic consumption in the postoperative period after adult tonsillectomy.
本研究旨在评估盐酸左布比卡因与地塞米松联合扁桃体周浸润用于成年患者扁桃体切除术后疼痛的疗效。
本双盲、随机、安慰剂对照研究共纳入40例患者。通过密封信封将患者等分为2组。研究组（SG）接受扁桃体周盐酸左布比卡因和地塞米松浸润，对照组（CG）接受扁桃体周生理盐水浸润。每组患者使用视觉模拟量表记录术后第2、4、8、12、16和24小时以及术后第2至7天的疼痛评分。记录每位患者的手术时长和术中失血总量。
研究组的所有疼痛评分均低于对照组；然而，在术后第2、12和16小时以及第2和3天差异有统计学意义（P<0.05）。两组术后并发症参数，包括耳痛、恶心、呕吐、发热、口臭和出血情况相似。扁桃体切除术后一周内，研究组的每日总镇痛药物消耗量显著低于对照组。
盐酸左布比卡因与地塞米松联合扁桃体周浸润可减轻成年患者扁桃体切除术后的疼痛并减少镇痛药物消耗。
