Buss D D, Bisgard G E, Rawlings C A, Rankin J H
Am J Physiol. 1975 May;228(5):1497-500. doi: 10.1152/ajplegacy.1975.228.5.1497.
Uteroplacental blood flow was measured by the radioactive-microsphere technique in eight near-term pregnant ewes during a normal control period and during maternal metabolic alkalosis. All measurements were made on awake, unanesthetized animals. Alkalosis, defined for this study as an arterial pH of 7.60 or greater, was produced by the oral administration of sodium bicarbonate, 3 g/kg body wt. The rise in pH thus produced was unaccompanied by significant changes in systemic arterial blood pressure and cardiac output, while maternal arterial Pco2 rose slightly from control levels. Cotyledonary blood flow declined from a control value of 1,177 ml/min to 1,025 ml/min during alkalosis. This decline of 13 percent in cotyledonary blood flow is significant (P smaller than 0.002). Blood flow to the remaining uterine tissue, or noncotyledonary uterus, did not change with alkalosis, being maintained at approximately 195 ml/min. It is concluded that maternal alkalosis, unaccompained by major changes in Pco2 and systemic arterial pressure, causes a small increase in the resistance of the uteroplacental circulation.
在正常对照期和母体代谢性碱中毒期间，采用放射性微球技术对8只近足月妊娠母羊的子宫胎盘血流进行了测量。所有测量均在清醒、未麻醉的动物身上进行。本研究将碱中毒定义为动脉pH值达到或高于7.60，通过口服3 g/kg体重的碳酸氢钠来诱发。由此产生的pH值升高并未伴随全身动脉血压和心输出量的显著变化，而母体动脉血二氧化碳分压从对照水平略有升高。在碱中毒期间，子叶血流从对照值1177 ml/min降至1025 ml/min。子叶血流下降13%具有统计学意义（P小于0.002）。流向其余子宫组织（即非子叶子宫）的血流在碱中毒时未发生变化，维持在约195 ml/min。结论是，母体碱中毒在未伴有二氧化碳分压和全身动脉压重大变化的情况下，会导致子宫胎盘循环阻力略有增加。
