Oakes G K, Walker A M, Ehrenkranz R A, Cefalo R C, Chez R A
J Appl Physiol. 1976 Aug;41(2):197-201. doi: 10.1152/jappl.1976.41.2.197.
The effect of induced maternal hyperthermia (1.5 degrees C rise over 60 min) on the uterine and umbilical circulations was examined in two groups of chronically instrumented pregnant sheep. Hyperventilation occurred in both groups. In the group in which the resultant respiratory alkalosis was untreated (N = 5), uterine blood flow decreased to 53 +/- 3% (mean +/- SE; P less than 0.01) of control at maximal maternal temperature. Umbilical blood flow also decreased 30 +/- 6% (P less than 0.01) below control levels. In the other group, normocapnia was maintained (N = 4). Uterine blood flow decreased in this group to 75% +/- 2% (P less than 0.01) of control levels, but umbilical blood flow did not significantly change. There was no significant change in maternal or fetal mean arterial pressure during hyperthermia in either group. Thus, maternal hyperthermia per se results in a significant decrease in uterine blood flow primarily through an effect on uterine vascular resistance, but without a concomitant change in umbilical blood flow.
在两组长期植入监测仪器的怀孕绵羊中，研究了诱导母体体温过高（60分钟内升高1.5摄氏度）对子宫和脐循环的影响。两组均出现了过度通气。在未治疗由此产生的呼吸性碱中毒的组（N = 5）中，在母体体温最高时，子宫血流量降至对照值的53±3%（平均值±标准误；P<0.01）。脐血流量也比对照水平降低了30±6%（P<0.01）。在另一组中（N = 4），维持了正常碳酸血症。该组子宫血流量降至对照水平的75%±2%（P<0.01），但脐血流量没有显著变化。两组在体温过高期间母体或胎儿平均动脉压均无显著变化。因此，母体体温过高本身主要通过对子宫血管阻力的影响导致子宫血流量显著减少，但脐血流量没有相应变化。
