Lipshitz J, Ahokas R A, Broyles K, Anderson G D
Am J Obstet Gynecol. 1986 Feb;154(2):310-4. doi: 10.1016/0002-9378(86)90662-9.
The effect of beta-adrenergic agonists on uteroplacental blood flow is controversial. Human studies, with the use of indirect methods to assess uteroplacental blood flow, show conflicting results. Animal studies in the near-term pregnant sheep model have the disadvantages that the sheep has a syndesmochorial placenta and that the uteroplacental vessels are thought to be maximally dilated near term. The effect of hexoprenaline, a new beta 2-sympathomimetic drug, was assessed in the awake pregnant rat on day 14 of gestation by means of the radionuclide-labeled microsphere method. Hexoprenaline increased placental blood flow by 198% and distribution of cardiac output to the placentas by 229%. Renal blood flow was reduced by 24%. Saline solution administration produced no significant effects.
β-肾上腺素能激动剂对子宫胎盘血流的影响存在争议。人体研究使用间接方法评估子宫胎盘血流，结果相互矛盾。在接近足月妊娠的绵羊模型上进行的动物研究存在以下缺点：绵羊具有结合绒毛膜胎盘，且子宫胎盘血管在接近足月时被认为已最大程度扩张。通过放射性核素标记微球法，在妊娠第14天对清醒的妊娠大鼠评估了一种新型β2-拟交感神经药物海索那林的作用。海索那林使胎盘血流增加了198%，心输出量向胎盘的分配增加了229%。肾血流量减少了24%。给予生理盐水未产生显著影响。
