Effect of vagal innervation on the secretory responses of canine gastric pouches exposed to bile.

The changes in the secretory response to a meat meal, after preliminary exposure of vagally innervated and vagally denervated fundic pouches to ox bile at pH 7 and pH 2, have been defined. In the innervated pouches, exposure to bile at both pH levels caused transient inhibition of gastric acid secretion. In both types of pouch, the output of Na+ in the gastric juice was presistently increased due to enhanced exchange diffusion. The changes were more pronounced after exposure to bile at pH 2 than after exposure to bile at pH 7. After exposure to bile, exchange diffusion was more increased in the innervated pouches than in the denervated. The results suggested that the innervated mucosa was more susceptible than was the denervated mucosa to the injurious effects of bile.