Hu Zeng-Yao, Xu Lan, Yan Rong, Huang Yan, Liu Gang, Zhou Wen-Xia, Zhang Yong-Xiang
Research Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China.
Zhongguo Zhong Yao Za Zhi. 2013 Feb;38(3):297-301.
Paeoniflorin (PF) is the chief active component of paeonia, with diverse pharmacological actions and wide application. Recently, the effect of PF on nervous system has attracted increasingly more attention. According to current study findings, PF can ameliorate the decline of memory and learning capacities in many dementia model animals, and have effect in protecting the cerebral ischemia injury, treating Parkinson's disease, reliving pain and improving neural synapse plasticity. Thought its mechanism has not been clarified, current findings show that adenosine A1 receptor plays an important role, while M cholinergic receptor, opiate receptor, calcium ion channel and NF-KB may also play a part in paeoniflorin's effect on nervous system.
芍药苷（PF）是芍药的主要活性成分，具有多种药理作用且应用广泛。近年来，PF对神经系统的作用日益受到关注。根据目前的研究结果，PF可改善多种痴呆模型动物的记忆和学习能力下降，对脑缺血损伤具有保护作用，可治疗帕金森病、缓解疼痛并改善神经突触可塑性。尽管其作用机制尚未阐明，但目前的研究结果表明，腺苷A1受体起重要作用，而M胆碱能受体、阿片受体、钙离子通道和核因子-κB可能也参与了芍药苷对神经系统的作用。
