National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW 2052, Australia.
Int J Psychophysiol. 2013 Sep;89(3):349-57. doi: 10.1016/j.ijpsycho.2013.05.002. Epub 2013 May 10.
For 35 years, some researchers have argued that CNV resolution may affect or even produce the increased P3 for NoGo compared to Go trials, and thus that no 'inhibitory' NoGo P3 exists. This is based on the work of Simson et al. (1977b), the scalp topography of potentials in auditory and visual Go/NoGo tasks. Electroencephalography and Clinical Neurophysiology, 43, 864-875, which compared Go and NoGo topography after CNV was subtracted from NoGo trials only. Specifically, the NoGo P3 topography showed the distinctive frontocentral maximum, which is often linked to motor inhibition, when referenced to a pre-target baseline. This NoGo topography changed to a more parietal maximum, similar to that on Go trials, when referenced to a pre-cue baseline. Many researchers have cited this study, while failing to use the delayed response design on which Simson et al. based their argument. We attempted to replicate Simson et al.'s experiment with delayed responses and also with immediate responses, as are more often used. As expected, the amplitudes of CNV and P3 to both Go and NoGo trials were increased when immediate compared to delayed responses were required, but we failed to replicate the topographic shift of NoGo P3 with different baselines for both delayed and immediate responses. That is, subtraction of the CNV from NoGo P3 did not change the distinctive frontocentral topography of this component. The results suggest that CNV may affect the amplitude and measurement of the NoGo P3, but that NoGo P3 anteriorisation is not caused by CNV resolution.
35 年来，一些研究人员认为，CNV 解析可能会影响甚至产生与 Go 试验相比，NoGo 试验中增加的 P3，因此并不存在“抑制性”的 NoGo P3。这是基于 Simson 等人的工作（1977b），即听觉和视觉 Go/NoGo 任务中电位的头皮地形图。脑电图和临床神经生理学，43,864-875，其中比较了仅从 NoGo 试验中减去 CNV 后 Go 和 NoGo 的地形图。具体来说，当参考预靶基线时，NoGo P3 地形图显示出独特的额中央最大值，这通常与运动抑制有关。当参考预线索基线时，这种 NoGo 地形图会变为更类似于 Go 试验的顶叶最大值。许多研究人员引用了这项研究，而没有使用 Simson 等人基于其论点的延迟反应设计。我们试图复制 Simson 等人的实验，包括延迟反应和更常用的即时反应。正如预期的那样，当需要即时反应而不是延迟反应时，CNV 和 Go 及 NoGo 试验的 P3 幅度都会增加，但我们未能复制不同基线的延迟和即时反应的 NoGo P3 地形图的转移。也就是说，从 NoGo P3 中减去 CNV 并没有改变该成分独特的额中央地形图。结果表明，CNV 可能会影响 NoGo P3 的幅度和测量，但 NoGo P3 的前中心化并不是由 CNV 解析引起的。
