Department of Toxicology, School of Public Health, China Medical University, 92 North 2nd Road, Heping District, Shenyang, 110001, Liaoning, People's Republic of China.
Arch Toxicol. 2013 Dec;87(12):2105-17. doi: 10.1007/s00204-013-1076-7. Epub 2013 May 14.
Exposure to rare earth elements (REEs) is known to impair intelligence in children and cause neurobehavioral abnormalities in animals. However, the mechanisms underlying these phenomena are not clear. Lanthanum is often used to study the effects of REEs. The aim of this study was to investigate the influence of lanthanum chloride (LaCl3) on spatial learning and memory and a possible underlying mechanism involving nuclear factor-kappa B (NF-κB) signalling pathway expression in the hippocampus. The rats were exposed to 0, 0.25, 0.50 or 1.00 % LaCl3 in drinking water during pregnancy and lactation (i.e. while feeding their offspring). After weaning, young rats continued to receive 0, 0.25, 0.50 and 1.00 % LaCl3 in the drinking water for 1 month. LaCl3 exposure impaired the spatial learning and memory of young rats and significantly decreased the expression of phosphorylated IκB kinase complex, phosphorylated IκBα, NF-κB, c-fos, c-jun and brain-derived neurotrophic factor in the hippocampus. These results indicate that LaCl3 exposure impairs spatial learning and memory in rats by inhibiting NF-κB signalling pathway.
暴露于稀土元素（REEs）已知会损害儿童的智力，并导致动物出现神经行为异常。然而，这些现象的机制尚不清楚。镧通常用于研究 REEs 的影响。本研究旨在探讨氯化镧（LaCl3）对空间学习和记忆的影响，以及海马核因子-κB（NF-κB）信号通路表达可能涉及的潜在机制。在妊娠和哺乳期（即喂养后代时），大鼠通过饮用水暴露于 0、0.25、0.50 或 1.00%的 LaCl3。断奶后，幼鼠继续在饮用水中接受 0、0.25、0.50 和 1.00%的 LaCl3 1 个月。LaCl3 暴露损害了幼鼠的空间学习和记忆，并显著降低了海马中磷酸化 IκB 激酶复合物、磷酸化 IκBα、NF-κB、c-fos、c-jun 和脑源性神经营养因子的表达。这些结果表明，LaCl3 通过抑制 NF-κB 信号通路来损害大鼠的空间学习和记忆。
