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Methylation of the promoter of brain-derived neurotrophic factor exon IV and antidepressant response in major depression.

作者信息

Tadić A, Müller-Engling L, Schlicht K F, Kotsiari A, Dreimüller N, Kleimann A, Bleich S, Lieb K, Frieling H

机构信息

Department of Psychiatry and Psychotherapy, University Medical Centre, Mainz, Germany.

Molecular Neuroscience Laboratory, Department of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School (MHH), Hanover, Germany.

出版信息

Mol Psychiatry. 2014 Mar;19(3):281-3. doi: 10.1038/mp.2013.58. Epub 2013 May 14.

DOI:10.1038/mp.2013.58
PMID:23670489
Abstract
摘要

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J Neurosci. 2012 Oct 10;32(41):14355-63. doi: 10.1523/JNEUROSCI.2156-12.2012.
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Mol Psychiatry. 2013 Apr;18(4):398-9. doi: 10.1038/mp.2012.38. Epub 2012 May 1.
3
A polymorphism associated with depressive disorders differentially regulates brain derived neurotrophic factor promoter IV activity.
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Trials. 2024 Apr 9;25(1):247. doi: 10.1186/s13063-024-08061-5.
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Environmental enrichment improves social isolation-induced memory impairment: The possible role of ITSN1-Reelin-AMPA receptor signaling pathway.环境丰容改善社交隔离诱导的记忆障碍：可能与 ITSN1- 络丝蛋白-AMPA 受体信号通路有关。
PLoS One. 2024 Jan 19;19(1):e0294354. doi: 10.1371/journal.pone.0294354. eCollection 2024.
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Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential.表观遗传学在重度抑郁症和其他与应激相关的障碍中的调节：分子机制、临床相关性和治疗潜力。
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Mechanisms Controlling the Expression and Secretion of BDNF.BDNF 的表达和分泌的调控机制。
Biomolecules. 2023 May 2;13(5):789. doi: 10.3390/biom13050789.
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Can Epigenetics Predict Drug Efficiency in Mental Disorders?表观遗传学能否预测精神障碍药物的疗效？
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DNA methylation profiles of the brain-derived neurotrophic factor (BDNF) gene as a potent diagnostic biomarker in major depression.脑源性神经营养因子（BDNF）基因的 DNA 甲基化谱作为重度抑郁症的潜在诊断生物标志物。
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Serum levels of brain-derived neurotrophic factor in major depressive disorder: state-trait issues, clinical features and pharmacological treatment.重性抑郁障碍患者血清脑源性神经营养因子水平：状态-特质问题、临床特征和药物治疗。
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The early non-increase of serum BDNF predicts failure of antidepressant treatment in patients with major depression: a pilot study.早期血清脑源性神经营养因子水平不增加可预测抑郁症患者抗抑郁治疗失败：一项初步研究。
Prog Neuropsychopharmacol Biol Psychiatry. 2011 Mar 30;35(2):415-20. doi: 10.1016/j.pnpbp.2010.08.011. Epub 2010 Aug 20.
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Increased BDNF promoter methylation in the Wernicke area of suicide subjects.自杀者韦尼克区脑源性神经营养因子启动子甲基化增加。
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The molecular neurobiology of depression.抑郁症的分子神经生物学
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Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications.血清脑源性神经营养因子、抑郁症与抗抑郁药物：荟萃分析及启示
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