Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, 199 Aba Khoushy Ave., Mount Carmel, Haifa 3498838, Israel.
Department of Human Biology, Faculty of Natural Sciences, University of Haifa, 199 Aba Khoushy Ave., Mount Carmel, Haifa 3498838, Israel.
Cells. 2023 Apr 17;12(8):1173. doi: 10.3390/cells12081173.
Psychiatric disorders affect millions of individuals and their families worldwide, and the costs to society are substantial and are expected to rise due to a lack of effective treatments. Personalized medicine-customized treatment tailored to the individual-offers a solution. Although most mental diseases are influenced by genetic and environmental factors, finding genetic biomarkers that predict treatment efficacy has been challenging. This review highlights the potential of epigenetics as a tool for predicting treatment efficacy and personalizing medicine for psychiatric disorders. We examine previous studies that have attempted to predict treatment efficacy through epigenetics, provide an experimental model, and note the potential challenges at each stage. While the field is still in its infancy, epigenetics holds promise as a predictive tool by examining individual patients' epigenetic profiles in conjunction with other indicators. However, further research is needed, including additional studies, replication, validation, and application beyond clinical settings.
精神障碍影响着全球数以百万计的个人及其家庭，其给社会带来的成本巨大，且由于缺乏有效的治疗方法，预计还会上升。个性化医疗——根据个人量身定制的治疗方案——提供了一个解决方案。尽管大多数精神疾病都受到遗传和环境因素的影响，但找到可以预测治疗效果的遗传生物标志物一直具有挑战性。这篇综述强调了表观遗传学作为预测治疗效果和为精神障碍患者制定个性化医疗方案的工具的潜力。我们检查了以前试图通过表观遗传学来预测治疗效果的研究，提供了一个实验模型，并指出了每个阶段的潜在挑战。虽然该领域仍处于起步阶段，但通过结合其他指标检查个体患者的表观遗传谱，表观遗传学有望成为一种预测工具。然而，还需要进一步的研究，包括更多的研究、复制、验证以及超出临床环境的应用。
