脉冲辐解研究还原型维生素 B₁₂ 复合物钴（Ⅱ）钴胺素与超氧自由基的反应。
Pulse radiolysis studies on the reaction of the reduced vitamin B₁₂ complex Cob(II)alamin with superoxide.
机构信息
Department of Chemistry & Biochemistry and School of Biomedical Sciences, Kent State University, Kent, OH 44242, USA.
出版信息
Chembiochem. 2013 Jun 17;14(9):1081-3. doi: 10.1002/cbic.201300229. Epub 2013 May 13.
Abstract
O₂.- scavenger: The rate constant for the rapid reaction of the ROS superoxide with the reduced vitamin B₁₂ radical complex cob(II)alamin was directly determined to be 3.8×10(8) M⁻¹ s⁻¹. This rate was independent of pH over the range 5.5-8.7. These results have implications for studying the use of B₁₂ supplements to combat diseases associated with oxidative stress.
摘要
O₂.- 清除剂：ROS 超氧自由基与还原型维生素 B₁₂ 自由基复合物 cob(II)alamin 的快速反应速率常数被直接确定为 3.8×10(8) M⁻¹ s⁻¹。该速率在 pH 值为 5.5-8.7 范围内与 pH 值无关。这些结果对于研究使用 B₁₂ 补充剂来对抗与氧化应激相关的疾病具有重要意义。
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