维生素 B(12)和氧化还原稳态： cob(II)alamin 与超氧化物的反应速率接近超氧化物歧化酶 (SOD)。
Vitamin B(12) and redox homeostasis: cob(II)alamin reacts with superoxide at rates approaching superoxide dismutase (SOD).
机构信息
Department of Chemistry, School of Biomedical Sciences, Kent State University, Kent, Ohio 44242, USA.
出版信息
J Am Chem Soc. 2009 Oct 28;131(42):15078-9. doi: 10.1021/ja904670x.
We report a kinetic study of the reaction between superoxide and an important intracellular form of vitamin B(12), cob(II)alamin. Superoxide is implicated in the pathophysiology of many inflammatory diseases, whereas vitamin B(12) derivatives are often beneficial in their treatment. We found that cob(II)alamin reacts with superoxide at rates approaching those of superoxide dismutase itself, suggesting a probable mechanism by which vitamin B(12) protects against chronic inflammation and modulates redox homeostasis.
我们报告了超氧阴离子与维生素 B(12)的一种重要的细胞内形式——钴胺素（cob(II)alamin）之间反应的动力学研究。超氧阴离子与许多炎症性疾病的病理生理学有关，而维生素 B(12)衍生物在其治疗中通常是有益的。我们发现，钴胺素（cob(II)alamin）与超氧阴离子的反应速率接近超氧化物歧化酶本身，这表明维生素 B(12)可能通过何种机制来预防慢性炎症和调节氧化还原平衡。
Zotero 插件