Chantefort A, Mahwachi M, Druilles J, Cassanas G, Jourdan R
Laboratoire d'Hygiène Hospitalière, Hôpital Lapeyronie, Montpellier.
Pathol Biol (Paris). 1990 May;38(5):477-82.
In France in 1990, there is no standardized method to study the bactericidal activity in vivo of antiseptics. A comparative study of the Williamson-Kligmann techniques (on the epidermis of the forearm) and of the bag of Gaschen (on the hands) has been carried out by using 11 products and 10 volunteers for each of them. On the forearm, the rates of reduction of the number of bacterias numbered in decimal logarithms are significantly much higher to those measured on the hand. After having stated the advantages and drawbacks of each of these two techniques, an account fort the differences in the activity that have been observed is suggested. None of these two techniques is universal and one or the other has to be used according to the therapeutic prescription (antisepsy of the normal skin or of the hands) of the patent medicine.
1990年在法国，没有标准化的方法来研究防腐剂在体内的杀菌活性。使用11种产品，并为每种产品安排10名志愿者，对威廉姆森-克利格曼技术（在前臂表皮上）和加申袋技术（在手上）进行了一项比较研究。在前臂上，以十进制对数表示的细菌数量减少率明显高于在手上测得的减少率。在阐述了这两种技术各自的优缺点之后，对观察到的活性差异给出了解释。这两种技术都不是通用的，必须根据专利药品的治疗处方（正常皮肤或手部的消毒）选择使用其中一种。
