Perapoch López J, Salcedo Abizanda S, Gallart Catalá A, Peguero Monforte G, Casellas Caro M, Barroso Pérez C, Fernández Pérez F, Rodríguez Garrido V
Servicio de Neonatología, Hospital Universitario Materno-Infantil Vall d'Hebrón, Universitat Autonoma de Barcelona.
An Esp Pediatr. 1993 Sep;39(3):195-8.
We report the results of a prospective study in which the effectiveness of 70% alcohol (A), mercurochrome (M), a solution of alcohol and mercurochrome (AM) and 1% chlorhexidine (C) as umbilical antiseptics was tested on 311 normal newborn infants. Similar results were obtained by using A, M, or AM; however, when C was used umbilical colonization was significantly reduced as compared to when the other three antiseptic agents were used. The umbilical cords that had been scrubbed with A, M or AM were detached by the 8th day after birth, whereas those treated with C took 14 days to fall off. The use of chlorhexidine resulted in a marked increase in pure cultures positive for Gram negative bacteria (Proteus spp. and Pseudomonas spp.) which was not the case with the other three antiseptics tested.
我们报告了一项前瞻性研究的结果，该研究在311名正常新生儿身上测试了70%酒精（A）、红汞（M）、酒精与红汞的混合溶液（AM）以及1%氯己定（C）作为脐带防腐剂的有效性。使用A、M或AM获得了相似的结果；然而，与使用其他三种防腐剂相比，使用C时脐带定植显著减少。用A、M或AM擦洗过的脐带在出生后第8天脱落，而用C处理的脐带需要14天才能脱落。使用氯己定导致革兰氏阴性菌（变形杆菌属和假单胞菌属）纯培养阳性显著增加，而其他三种测试的防腐剂则没有这种情况。
