Ulmer Miriam, Lademann Juergen, Patzelt Alexa, Knorr Fanny, Kramer Axel, Koburger Torsten, Assadian Ojan, Daeschlein Georg, Lange-Asschenfeldt Bernhard
Center for Experimental and Applied Cutaneous Physiology, Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Skin Pharmacol Physiol. 2014;27(6):283-92. doi: 10.1159/000357387. Epub 2014 Jun 26.
During the past decades, encouraging progress has been made in the prevention of surgical site infections (SSI). However, as SSI still occur today, strategic prevention measures such as standardized skin antisepsis must be implemented and rigorously promoted. Recent discoveries in skin physiology necessitate the development of novel antiseptic agents and procedures in order to ameliorate their efficacy. In particular, alternate target structures in the skin need to be taken into consideration for the development of the next generation of antiseptics. Recent investigations have shown that a high number of microorganisms are located within and in the close vicinity of the hair follicles. This suggests that these structures are an important reservoir of bacterial growth and activity in human skin. To date, it has not been fully elucidated to what extent conventional liquid antiseptics sufficiently target the hair follicle-related microbial population. Modern technologies such as tissue-tolerable plasma (TTP) have been tested for their potential antiseptic efficiency by reducing the bacterial load in the skin and in the hair follicles. First experiments using liposomes to deliver antiseptics into the hair follicles have been evaluated for their potential clinical application. The present review evaluates these two innovative methods for their efficacy and applicability in preoperative skin antiseptics.
在过去几十年中，手术部位感染（SSI）的预防取得了令人鼓舞的进展。然而，由于如今SSI仍有发生，必须实施并严格推广标准化皮肤消毒等战略预防措施。皮肤生理学的最新发现使得有必要开发新型抗菌剂和程序，以提高其功效。特别是，在开发下一代抗菌剂时，需要考虑皮肤中的替代靶标结构。最近的研究表明，大量微生物位于毛囊内部及其附近。这表明这些结构是人类皮肤中细菌生长和活动的重要储存库。迄今为止，传统液体抗菌剂对毛囊相关微生物群的靶向程度尚未完全阐明。诸如组织耐受等离子体（TTP）等现代技术已通过减少皮肤和毛囊中的细菌载量来测试其潜在的抗菌效率。使用脂质体将抗菌剂递送至毛囊的首次实验已评估其潜在的临床应用价值。本综述评估了这两种创新方法在术前皮肤消毒中的功效和适用性。
