University Paris 12, CHI Creteil, Creteil, France.
PLoS One. 2013 May 6;8(5):e62140. doi: 10.1371/journal.pone.0062140. Print 2013.
To determine risk factors of superimposed preeclampsia in women with essential chronic hypertension receiving antihypertensive therapy prior to conception.
A retrospective study of 211 patients that analyzed risk factors of superimposed preeclampsia at first prenatal visit. Variables with a p<.1 at univariate analysis were included in a logistic regression analysis. P<.05 was considered as significant.
Superimposed preeclampsia occurred in 49 (23.2%) women. In logistic regression analysis, previous preeclampsia [OR: 4.05 (1.61-10.16)], and mean arterial blood pressure of 95 mmHg or higher [OR: 4.60 (1.94-10.93)] were associated with increased risk of superimposed preeclampsia. When both variables were present, sensitivity, specificity, positive predictive value, negative predictive value, and likelihood ratio for superimposed preeclampsia were 43%, 94%, 70%, 85%, and 7.71 (95% CI: 3.20-18.57), respectively.
In essential chronic hypertensive women, previous preeclampsia and mean arterial blood pressure of 95 mmHg or higher are associated with increased risks of superimposed preeclampsia.
确定在受孕前接受抗高血压治疗的原发性慢性高血压女性中，子痫前期的重叠危险因素。
对 211 名患者进行回顾性研究，在首次产前检查时分析子痫前期的重叠危险因素。单因素分析中 p<.1 的变量被纳入逻辑回归分析。p<.05 被认为具有统计学意义。
49 名（23.2%）女性发生子痫前期重叠。在逻辑回归分析中，既往子痫前期[OR：4.05（1.61-10.16）]和平均动脉压为 95mmHg 或更高[OR：4.60（1.94-10.93）]与子痫前期重叠的风险增加相关。当两个变量都存在时，子痫前期重叠的敏感性、特异性、阳性预测值、阴性预测值和似然比分别为 43%、94%、70%、85%和 7.71（95%CI：3.20-18.57）。
在原发性慢性高血压女性中，既往子痫前期和平均动脉压为 95mmHg 或更高与子痫前期重叠的风险增加相关。
