Kohno Emiko
Department of Hospital Pharmacy, Kansai Medical University, Kori Hospital, Neyagawa 572-8551, Japan.
Rinsho Byori. 2013 Feb;61(2):118-26.
Treatment of infections is a team medical care operation, utilizing the coordinated expertise of many different professionals. Among these, the duty of the pharmacist, as a drug specialist, is considered to be related to the proper use of antibacterial drugs. When selecting an antibacterial drug, it is important to understand the severity and infection source of the patient, and consider drug susceptibility and tissue transitivity based on the antibiogram at the hospital. Moreover, consideration of the specific clinical conditions of pregnant or nursing women, and children, as well as any organ dysfunctions, is required to determine the appropriate antibacterial drug and its proper use. The dosage and administration method of the selected antibacterial drug are determined based on factors such as PK-PD parameters and organ dysfunction of the patient. For drugs requiring TDM, implementation of TDM, determination and evaluation of efficacy, and suggestions to change the antibacterial drug, its dosage, or administration method when needed, are all considered to play a part in the treatment of infection. The duty of the pharmacist is to promote the proper use of antibacterial drugs and participate in the treatment of patients. Moreover, since the proper use of an antibacterial drug and effective use of PK-PD parameters lead to prevention of the emergence of resistant bacteria, we would like to contribute to the preservation of antibacterial drugs as well.
感染治疗是一项团队医疗护理工作，需要许多不同专业人员的协同专业知识。其中，药剂师作为药物专家，其职责被认为与抗菌药物的合理使用有关。选择抗菌药物时，了解患者的病情严重程度和感染源很重要，并要根据医院的抗菌谱考虑药物敏感性和组织通透性。此外，确定合适的抗菌药物及其正确使用方法时，需要考虑孕妇、哺乳期妇女、儿童的具体临床情况以及任何器官功能障碍。所选抗菌药物的剂量和给药方法根据患者的药代动力学-药效学参数和器官功能障碍等因素来确定。对于需要进行血药浓度监测（TDM）的药物，实施TDM、疗效的确定和评估，以及在需要时更改抗菌药物、其剂量或给药方法的建议，都被认为在感染治疗中发挥作用。药剂师的职责是促进抗菌药物的合理使用并参与患者治疗。此外，由于抗菌药物的合理使用和药代动力学-药效学参数的有效利用可防止耐药菌的出现，我们也希望为抗菌药物的保存做出贡献。
