Gan Di, Zhang Changqing
Department of Orthopedics, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, 200233, P.R. China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2013 Mar;27(3):365-8.
To review the research progress of alcohol-induced osteonecrosis of the femoral head (ONFH).
Recent literature concerning alcohol-induced ONFH was reviewed and summarized.
Alcohol-induced ONFH accounte for approximately 1/3 of total ONFH. Alcohol intake and the incidence of ONFH has a significant dose-effect relationship. There are some correlations between alcohol-induced ONFH and lipid metabolism, secretion of corticosteroid, and some gene of alcohol or lipid metabolism.
The relationships between alcohol and lipid metabolism, and between alcohol and steroid are still the main direction of the research of ONFH. Gene level researches can not demonstrate the pathogenesis, therefore further research should be carried on.
综述酒精性股骨头坏死（ONFH）的研究进展。
回顾并总结近期关于酒精性ONFH的文献。
酒精性ONFH约占ONFH总数的1/3。酒精摄入量与ONFH发病率存在显著的剂量效应关系。酒精性ONFH与脂质代谢、皮质类固醇分泌以及一些酒精或脂质代谢基因之间存在一定关联。
酒精与脂质代谢以及酒精与类固醇之间的关系仍是ONFH研究的主要方向。基因水平的研究尚不能阐明发病机制，因此应进一步开展研究。
