Interdisciplinary Nanoscience Center, Faculty of Science and Technology, Aarhus University, Aarhus, Denmark.
Biomaterials. 2013 Aug;34(24):5883-90. doi: 10.1016/j.biomaterials.2013.04.031. Epub 2013 May 11.
Studies have indicated systemic treatment with strontium (Sr) as a potential route to increase bone quality and formation around osseointegrating implants. However, adverse effects are linked to such treatment. In this study we present a surface modification method designed for sustained local release of Sr from implants. The four groups used were prepared by a magnetron co-sputtering process and selected on the basis of Sr release data. The composition, morphology and mechanical stability of the coatings were analyzed and the Sr release profiles were investigated in vitro by washout experiments. Mesenchymal stem cells were cultured on the different coatings to evaluate potential cytotoxic effects and the effect on cellular proliferation. No indication of toxicity was found. A rodent study demonstrated a significant increase in direct bone-to-implant contact and peri-implant bone volume, for several of the groups, four weeks after implantation when compared to a Grade 4 titanium reference group. Median values of bone-to-implant contact and new bone formation was found to be 19% and 53%, respectively, for the best group compared to 0% for both parameters with respect to the Grade 4 titanium reference. The results indicate that this method may have applications within the orthopedic and dental industry.
研究表明，锶（Sr）的全身治疗是一种潜在的方法，可以增加骨整合种植体周围的骨质量和形成。然而，这种治疗与不良反应有关。在这项研究中，我们提出了一种表面改性方法，旨在从植入物中持续局部释放 Sr。使用磁控共溅射工艺制备了四组，并根据 Sr 释放数据进行了选择。分析了涂层的组成、形态和机械稳定性，并通过冲洗实验研究了 Sr 的释放曲线。将间充质干细胞培养在不同的涂层上，以评估潜在的细胞毒性和对细胞增殖的影响。未发现毒性迹象。动物研究表明，与 4 级钛参考组相比，植入后四周，几种植入物的直接骨-植入物接触和植入物周围骨量显著增加。与 4 级钛参考组相比，最佳组的骨-植入物接触中位数和新骨形成中位数分别为 19%和 53%，而这两个参数均为 0%。结果表明，该方法可能在矫形和牙科行业中有应用。
