Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Chin Med J (Engl). 2013;126(10):1944-7.
Previous studies suggest a link between macular edema and retinal blood flow velocity (RBFV). The effects of inflammation in the retinal blood vessels are not clearly understood. We want to evaluate the differences in retinal blood flow velocities of patients with active uveitis and healthy controls using the retinal function imager (RFI) and determine the correlation between retinal blood flow velocity and central macular thickness in uveitis patients.
Twenty-eight eyes of 24 patients with active anterior uveitis and 51 eyes of 51 normal control subjects were enrolled. Retinal blood flow velocities evaluated by RFI and central macular thickness evaluated by optical coherence tomography (SLO-OCT) were obtained. Differences among the groups were assessed using Stata statistical software.
Ten eyes had uveitic cystoid macular edema (CME). Median (first quartile, third quartile) venous velocity for uveitic eyes with CME, uveitic eyes without CME, and controls were 2.09 (1.92, 2.44), 2.64 (2.32, 2.86), and 2.82 (2.39, 3.53) mm/s respectively. Median (first and quartile) arterial velocity for uveitic eyes with CME, uveitic eyes without CME, and controls were 3.79 (3.61, 4.09), 3.46 (2.86, 4.12), and 3.93 (3.35, 4.65) mm/s. Uveitic eyes with CME had significantly lower venous velocity than controls (P = 0.044). There was a strong linear relationship between venous velocity and central retinal thickness (P = 0.007).
Retinal venous velocities were significantly decreased in eyes with uveitic CME relative to controls. Decreased venous velocity was correlated with increased central retinal thickness in uveitic eyes.
先前的研究表明黄斑水肿与视网膜血流速度（RBFV）之间存在关联。然而，视网膜血管中炎症的影响尚不清楚。我们希望使用视网膜功能成像仪（RFI）评估活动期葡萄膜炎患者与健康对照者的视网膜血流速度差异，并确定葡萄膜炎患者的视网膜血流速度与中心性视网膜厚度之间的相关性。
共纳入 24 例活动期前葡萄膜炎患者的 28 只眼和 51 例健康对照者的 51 只眼。使用 RFI 评估视网膜血流速度，使用 SLO-OCT 评估中心性视网膜厚度。使用 Stata 统计软件评估组间差异。
10 只眼患有葡萄膜炎性囊样黄斑水肿（CME）。CME 组、无 CME 组和对照组的静脉血流速度中位数（四分位距）分别为 2.09（1.92，2.44）、2.64（2.32，2.86）和 2.82（2.39，3.53）mm/s。CME 组、无 CME 组和对照组的动脉血流速度中位数（四分位距）分别为 3.79（3.61，4.09）、3.46（2.86，4.12）和 3.93（3.35，4.65）mm/s。CME 组的静脉血流速度明显低于对照组（P=0.044）。静脉血流速度与中心性视网膜厚度之间存在强烈的线性关系（P=0.007）。
与对照组相比，患有葡萄膜炎性 CME 的眼的视网膜静脉血流速度显著降低。葡萄膜炎眼的静脉血流速度降低与中心性视网膜厚度增加相关。
