Binesh Fariba, Akhondei Mohsen, Pourmirafzali Hamideh, Rajabzadeh Yavar
Department of Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
J Coll Physicians Surg Pak. 2013 May;23(5):326-9.
To determine eosinophil and mast cell populations in gastric and duodenal mucosal biopsies of adults with nonulcer dyspepsia (NUD) as compared to non-dyspeptic adults.
A case control study.
Shahid Sadoughi University of Medical Sciences, Yazd, Iran, from January 2010 to June 2011.
A total of 52 (25 non-ulcer dyspeptic patients as case and 27 non-dyspeptic patients as control) patients underwent endoscopy. All patients had a minimum of 2 forceps biopsies obtained from stomach and duodenum. Routine histological evaluation was performed and additionally evaluated to determine eosinophil and mast cell counts. The statistical analysis was performed on SPSS version 17.0, using Mann-Whitney test with significance at p < 0.05.
The mean age in the case and control groups was 31.72 ± 12.17 and 35.74 ± 12.42 years respectively. The median eosinophil density in gastric mucosa in case group was 5.0 (ranging from 1 to 20) and 4.0 in control group (ranging from 0 to 16; p = 0.140). The median eosinophil density in duodenal mucosa in case group was 16.0 (ranging from 2 to 24) and 13 in control group (ranging from 2 to 45; p = 0.147). The median mast cell density in gastric mucosa in case group was 4.0 (ranging from 0 to 33) and 4.0 in control group (ranging from 0 to 26; p = 0.827). The median mast cell density in duodenal mucosa in case group was 4.0 (ranging from 0 to 31) and 3.0 in control group (ranging from 1 to 23; p = 0.704). The frequency of Helicobacter pylori infection in both the groups was similar.
Although there were not statistically significant differences in eosinophil and mast cell densities between case and control groups, there was a trend toward mild eosinophilia in gastric and duodenal mucosa. The specific role of eosinophils and mast cells in NUD is yet to be completely defined.
确定非溃疡性消化不良（NUD）成人与无消化不良的成人相比，胃和十二指肠黏膜活检中的嗜酸性粒细胞和肥大细胞数量。
病例对照研究。
2010年1月至2011年6月，伊朗亚兹德的沙希德·萨杜基医科大学。
共有52例患者接受了内镜检查（25例非溃疡性消化不良患者为病例组，27例无消化不良患者为对照组）。所有患者至少从胃和十二指肠获取2次钳取活检组织。进行常规组织学评估，并额外评估以确定嗜酸性粒细胞和肥大细胞计数。使用SPSS 17.0版进行统计分析，采用Mann-Whitney检验，显著性水平为p < 0.05。
病例组和对照组的平均年龄分别为31.72 ± 12.17岁和35.74 ± 12.42岁。病例组胃黏膜嗜酸性粒细胞密度中位数为5.0（范围为1至20）,对照组为4.0（范围为0至16；p = 0.140）。病例组十二指肠黏膜嗜酸性粒细胞密度中位数为16.0（范围为2至24），对照组为13（范围为2至45；p = 0.147）。病例组胃黏膜肥大细胞密度中位数为4.0（范围为0至33），对照组为4.0（范围为0至26；p = 0.827）。病例组十二指肠黏膜肥大细胞密度中位数为4.0（范围为0至31），对照组为3.0（范围为1至23；p = 0.704）。两组幽门螺杆菌感染率相似。
虽然病例组和对照组之间嗜酸性粒细胞和肥大细胞密度无统计学显著差异，但胃和十二指肠黏膜有轻度嗜酸性粒细胞增多的趋势。嗜酸性粒细胞和肥大细胞在NUD中的具体作用尚未完全明确。
