Hayatbakhsh Abbasi Mohammad Mahdi, Jafari Elham, Zahedi Mohammadjavad, Darvish Moghaddam Sodaif, Taghizadeh Aboozar, Kharazmi Negin
Professor of Internal Medicine, Gastroenterology and Hepatology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Associate Professor, Pathology and stem cells Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Middle East J Dig Dis. 2021 Oct;13(4):333-338. doi: 10.34172/mejdd.2021.243. Epub 2021 Sep 13.
BACKGROUND Functional dyspepsia is a common, troubling, and usually chronic disorder. Although the merit of using pathological assays has not been confirmed, medications affecting eosinophils may result in some improvements. Disseminated distribution of mast cells may also be an essential factor. Given the probable associations and lack of evidenced-based data, this study was conducted to comparatively investigate the number of eosinophils and mast cells in the duodenum in functional dyspepsia patients and healthy controls. METHODS In this case-control study, 150 consecutive subjects in Kerman, Iran, were enrolled in 2015 and 2016; the subjects consisted of 100 patients with functional dyspepsia and 50 asymptomatic healthy controls. Samples from the two groups were compared for the number of eosinophils, mast cells, and Helicobacter pylori presence by grasp biopsy. RESULTS The mean number of mast cells significantly differed between the groups (P = 0.001), but the eosinophil count was similar ( > 0.05). Female gender, no opioid use, and H. pylori may increase mast cell count ( < 0.05). CONCLUSION Overall, the mast cell count was significantly different between people with functional dyspepsia and people without it, but the eosinophil count in the two groups was similar.
背景 功能性消化不良是一种常见、令人困扰且通常为慢性的疾病。尽管使用病理检测的价值尚未得到证实，但影响嗜酸性粒细胞的药物可能会带来一些改善。肥大细胞的弥漫性分布也可能是一个重要因素。鉴于可能存在的关联以及缺乏循证数据，本研究旨在比较功能性消化不良患者和健康对照者十二指肠中嗜酸性粒细胞和肥大细胞的数量。
方法 在这项病例对照研究中，2015年和2016年在伊朗克尔曼连续纳入了150名受试者；受试者包括100名功能性消化不良患者和50名无症状健康对照者。通过钳取活检比较两组样本中嗜酸性粒细胞、肥大细胞的数量以及幽门螺杆菌的存在情况。
结果 两组之间肥大细胞的平均数量有显著差异（P = 0.001），但嗜酸性粒细胞计数相似（P>0.05）。女性、未使用阿片类药物以及幽门螺杆菌可能会增加肥大细胞计数（P<0.05）。
结论 总体而言，功能性消化不良患者与非功能性消化不良患者之间的肥大细胞计数存在显著差异，但两组的嗜酸性粒细胞计数相似。
