多种途径导致毛囊干细胞再生受损进而引发脱发。
Many paths to alopecia via compromised regeneration of hair follicle stem cells.
机构信息
Department of Dermatology, XiangYa Hospital, Central South University, Changsha, China.
出版信息
J Invest Dermatol. 2013 Jun;133(6):1450-2. doi: 10.1038/jid.2012.511.
Abstract
Alopecia can be caused by defective formation, defective regeneration, or increased destruction of hair follicles. Much work has elucidated the roles of diffusible morphogens in modulating hair follicle stem cell activities. Recent studies have revealed novel molecular events within the nucleus, which are required for the activation and progression of hair stem cells. These studies will provide new clues and targets for designing therapeutic strategies for hair loss.
摘要
脱发可由毛囊形成缺陷、再生缺陷或破坏增加引起。大量研究阐明了可扩散形态发生因子在调节毛囊干细胞活性方面的作用。最近的研究揭示了细胞核内激活和促进毛干细胞所需的新分子事件。这些研究将为设计脱发治疗策略提供新的线索和靶点。
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本文引用的文献
1
Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering.毛发再生的治疗策略：毛囊周期激活、微环境调节、创伤诱导的毛囊新生和干细胞工程。
Expert Opin Biol Ther. 2013 Mar;13(3):377-91. doi: 10.1517/14712598.2013.739601. Epub 2013 Jan 5.
2
Yap controls stem/progenitor cell proliferation in the mouse postnatal epidermis.Yap 控制小鼠出生后表皮中的干细胞/祖细胞增殖。
J Invest Dermatol. 2013 Jun;133(6):1497-505. doi: 10.1038/jid.2012.430. Epub 2012 Nov 29.
3
Roles of MED1 in quiescence of hair follicle stem cells and maintenance of normal hair cycling.MED1 在毛囊干细胞静止和维持正常毛发周期中的作用。
J Invest Dermatol. 2013 Feb;133(2):354-60. doi: 10.1038/jid.2012.293. Epub 2012 Aug 30.
4
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J Invest Dermatol. 2012 Nov;132(11):2505-21. doi: 10.1038/jid.2012.182. Epub 2012 Jul 5.
5
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6
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Physiology (Bethesda). 2012 Apr;27(2):61-72. doi: 10.1152/physiol.00028.2011.
7
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9
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J Invest Dermatol. 2012 Apr;132(4):1075-83. doi: 10.1038/jid.2011.430. Epub 2011 Dec 22.
10
Self-organizing and stochastic behaviors during the regeneration of hair stem cells.毛发干细胞再生过程中的自组织和随机行为。
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