Centre de Recherches des Cordeliers, INSERM, UMR S 872, 15, rue de L'école de médecine, 75006, Paris, France.
Apoptosis. 2013 Sep;18(9):1048-59. doi: 10.1007/s10495-013-0862-2.
Programmed cell death is an important factor in tissue homeostasis. Lot of work has been performed to characterize the caspase-dependent cell death. Caspase-independent cell death, although important in many physiological situations, is less investigated. In this work we show that two caspase-independent effectors of cell death, namely apoptosis-inducing factor and leukocyte elastase inhibitor derived DNase II interact and can cooperate to induce cell death. These results contribute to the knowledge of molecular pathways of cell death, an important issue in the development of new therapeutic strategies for the treatment of cancer or neurodegenerative diseases.
程序性细胞死亡是组织稳态的一个重要因素。大量工作已经致力于描述依赖半胱天冬酶的细胞死亡。虽然非依赖半胱天冬酶的细胞死亡在许多生理情况下很重要，但研究较少。在这项工作中，我们表明两种非依赖半胱天冬酶的细胞死亡效应物，即凋亡诱导因子和白细胞弹性蛋白酶抑制剂衍生的 DNase II 相互作用，并可以协同诱导细胞死亡。这些结果有助于了解细胞死亡的分子途径，这是开发治疗癌症或神经退行性疾病的新治疗策略的重要问题。
