Loos U, Marklein G, Scholl H, Schwabe H K
Medizinische Universitätsklinik Bonn.
Pneumologie. 1990 Feb;44 Suppl 1:312-3.
We determined ciprofloxacin levels in plasma, saliva, bronchial secretions, lavage fluid, and alveolar macrophages in 9 patients five hours following the last administration of the drug (2 x 750 mg ciprofloxacin daily over a period of at least 3 days). The ciprofloxacin concentration in the alveolar film was determined using urea as internal marker for the lavage. On average it was 2.51 micrograms/ml (= 186% of the plasma level), and clearly exceeded the minimal inhibition concentrations for the facultative pathogenic organism. This means that, in the alveolar film--which represents the barrier to descending pneumonia--an effective accumulation of the quinolone takes place.
我们测定了9名患者在最后一次给药（至少3天内每日2次，每次750毫克环丙沙星）5小时后血浆、唾液、支气管分泌物、灌洗液和肺泡巨噬细胞中的环丙沙星水平。使用尿素作为灌洗的内标物来测定肺泡膜中环丙沙星的浓度。平均浓度为2.51微克/毫升（相当于血浆水平的186%），明显超过了兼性致病生物体的最低抑菌浓度。这意味着，在代表下行性肺炎屏障的肺泡膜中，喹诺酮类药物发生了有效的蓄积。
