VEGF-C、VEGFR-3和环氧化酶-2在早期宫颈癌中的临床病理意义

Clinicopathological Significance of VEGF-C, VEGFR-3 and Cyclooxygenase-2 in Early-Stage Cervical Cancer.

作者信息

Shi Xiaoyan, Xi Ling, Weng Danhui, Chen Gang, Song Xiaohong, Wu Peng, Wang Beibei, Wei Juncheng, Wang Shixuan, Zhou Jianfeng, Ma Ding

机构信息

Cancer biology research center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, P.R. China; ; Department of Oncology, Renmin Hospital, Yunyan Medical College, 23 Chaoyang road Shiyan, Hubei, P.R. China.

出版信息

Int J Biomed Sci. 2008 Mar;4(1):58-63.

PMID:23675067

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3614667/

Abstract

To investigate the roles of VEGF-C, VEGFR-3 and cyclooxygenase-2 (COX-2) in tumor progression and lymph node metastasis. The expression of VEGF-C, VEGFR-3 and COX-2 were examined in 93 cases of surgical speciments of cervical diseases by immunohistochemical staining. The correlation between expression of these factors and tumor aggressiveness was evaluated. The expression levels of VEGF-C and COX-2 were much higher in cervical cancer than in cervical intraepithelial neoplasia (CIN) and in chronic cervicitis. VEGF-C expression correlated with lymph node metastases (P<0.01). Multivariate analysis indicated that lymph vessel density (LVD) was associated with the coexpression of VEGF-C and COX-2. Expression of VEGF-C and VEGFR-3 were both in coincidence with lymph node metastasis. VEGF-C and COX-2 may promote the canceration of cervical cancer and that VEGF-C/ VEGFR-3 system had a significant association with the lymphagiogenesis and lymph node metastasis.

摘要

探讨血管内皮生长因子C（VEGF-C）、血管内皮生长因子受体3（VEGFR-3）和环氧合酶-2（COX-2）在肿瘤进展及淋巴结转移中的作用。采用免疫组织化学染色法检测93例宫颈疾病手术标本中VEGF-C、VEGFR-3和COX-2的表达情况。评估这些因子的表达与肿瘤侵袭性之间的相关性。宫颈癌中VEGF-C和COX-2的表达水平显著高于宫颈上皮内瘤变（CIN）和慢性宫颈炎。VEGF-C表达与淋巴结转移相关（P<0.01）。多因素分析表明，淋巴管密度（LVD）与VEGF-C和COX-2的共表达相关。VEGF-C和VEGFR-3的表达均与淋巴结转移一致。VEGF-C和COX-2可能促进宫颈癌的发生，且VEGF-C/VEGFR-3系统与淋巴管生成及淋巴结转移显著相关。