通过3-(2-氨基烷基)-2-(苯基氨基)喹唑啉-4(3H)-酮的分子内环化反应合成三环喹唑啉酮。
Synthesis of tricyclic quinazolinones via intramolecular cyclization of 3-(2-aminoalkyl)-2-(phenylamino)quinazolin-4(3H)-ones.
作者信息
Yang Xuhong, Wu Minghu, Sun Shaofa, Huang Changfeng, Guo Haibing, Wang Jian, Lee John, Xing Yalan
机构信息
Hubei Collaborative Innovation Centre for Non-power Nuclear Technology, College of Neuclear Technology & Chemistry and Biology, Hubei University of Science and Technology, Xianning, 437100, China.
Bennett Department of Chemistry, West Virginia University, Morgantown, WV, 26506, USA.
出版信息
Mol Divers. 2016 May;20(2):551-6. doi: 10.1007/s11030-015-9636-9. Epub 2015 Oct 15.
Bioactive tricyclic quinazolines class of 3,4-dihydro-1H-pyrimido[2,1-b]quinazolin-6(2H)-ones I and 2,3-dihydroimidazo[2,1-b]quinazolin-5(1H)-ones II were synthesized by the formic acid-catalyzed intramolecular cyclization of 3-(2-aminoalkyl)-2-(phenylamino)quinazolin-4(3H)-ones 1 in high yields. A plausible mechanism of the cyclization step is proposed.
通过甲酸催化3-(2-氨基烷基)-2-(苯基氨基)喹唑啉-4(3H)-酮1的分子内环化反应，高产率地合成了具有生物活性的三环喹唑啉类化合物3,4-二氢-1H-嘧啶并[2,1-b]喹唑啉-6(2H)-酮I和2,3-二氢咪唑并[2,1-b]喹唑啉-5(1H)-酮II。提出了环化步骤的合理机制。
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