College of Chemistry, Jilin University, Changchun, 130012, China.
Environ Sci Pollut Res Int. 2013 Dec;20(12):8567-78. doi: 10.1007/s11356-013-1795-6. Epub 2013 May 16.
Group-selective magnetic molecularly imprinted polymers (MMIPs) that can extract four widely used sulfonamide antibiotics and their acetylated metabolites from environmental water were synthesized in this study. The MMIPs with saturation magnetization value of 16.7 emu g(-1) could be separated from the environmental water samples easily by the application of an adscititious magnetic field, reducing the time consumption of pretreatment. The extraction conditions were evaluated, and optimal extraction conditions were as follows: extraction time, 25 min; amount of polymers, 90 mg; washing solvent, 30 % methanol aqueous solution; and elution solvent, methanol-acetic acid (95:5, v/v). The target analytes were detected by liquid chromatography-tandem mass spectrometry, and the detection limits of the method are in the range of 0.38-1.32 ng L(-1). The relative standard deviations of intra- and inter-day are in the range of 1.3-6.8 % and 1.7-9.1 %, respectively. The proposed method is suitable for the analysis of environmental water samples.
本研究合成了可从环境水样中萃取四种广泛使用的磺胺类抗生素及其乙酰化代谢物的组选择性磁性分子印迹聚合物（MMIPs）。具有 16.7 emu g(-1)饱和磁化强度值的 MMIPs 可通过外加磁场轻松从环境水样中分离出来，从而减少了预处理的时间消耗。评估了萃取条件，最佳萃取条件如下：萃取时间 25 min；聚合物用量 90 mg；洗涤溶剂为 30%甲醇水溶液；洗脱溶剂为甲醇-乙酸（95:5，v/v）。采用液相色谱-串联质谱法检测目标分析物，该方法的检测限范围为 0.38-1.32 ng L(-1)。日内和日间相对标准偏差分别在 1.3-6.8%和 1.7-9.1%范围内。该方法适用于环境水样的分析。
