Xu Yang, Zhao Qi, Jiang Liyan, Li Zhengqiang, Chen Yanhua, Ding Lan
College of Life Sciences, Jilin University, 2699 Qianjin Street, Changchun, 130012, China.
College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, 130012, China.
Environ Sci Pollut Res Int. 2017 Apr;24(10):9174-9186. doi: 10.1007/s11356-017-8581-9. Epub 2017 Feb 18.
In the study, a simple and selective method based on magnetic separation technology is presented for the extraction of sulfonamides (SAs) from environmental water, followed by liquid chromatography-tandem mass spectrometry. In this method, magnetic surface molecularly imprinted polymers (FeO@SiO@MIPs) with super-paramagnetic property and high selectivity toward SAs were developed as magnetic adsorbents. The FeO@SiO@MIPs were then applied to the selective extraction of SAs from environmental water. The extraction and enrichment were accomplished simultaneously in a single step by simply stirring the mixture of adsorbents and water samples. The FeO@SiO@MIPs were characterized by scanning electron microscopy, Fourier-transform infrared spectrometry, and vibrating sample magnetometry. The adsorption thermodynamics and kinetics were employed to study the adsorption mechanism of the FeO@SiO@MIPs. And the matrix effect of the method was evaluated. Calibration curves obtained by analyzing matrix-matched standards show excellent linear relationship (R = 0.9994-0.9999) in the concentration range of 10-1000 ng L, and the limits of detection are in the range of 1.4-2.8 ng L. The relative standard deviations of intra- and inter-day obtained are in the range of 2.8 to 7.8 and 3.1 to 7.9%, respectively. The proposed method was successfully applied to determine SAs in six environmental water samples, and SAs were detectable in four of them with the concentration from 10.5 to 120.2 ng L.
在本研究中，提出了一种基于磁分离技术的简单且具有选择性的方法，用于从环境水样中提取磺胺类药物（SAs），随后进行液相色谱 - 串联质谱分析。在该方法中，开发了具有超顺磁性且对SAs具有高选择性的磁性表面分子印迹聚合物（FeO@SiO@MIPs）作为磁性吸附剂。然后将FeO@SiO@MIPs应用于从环境水样中选择性提取SAs。通过简单搅拌吸附剂和水样的混合物，在单个步骤中同时完成提取和富集。通过扫描电子显微镜、傅里叶变换红外光谱和振动样品磁强计对FeO@SiO@MIPs进行了表征。采用吸附热力学和动力学研究FeO@SiO@MIPs的吸附机制。并评估了该方法的基质效应。通过分析基质匹配标准获得的校准曲线在10 - 1000 ng/L的浓度范围内显示出良好的线性关系（R = 0.9994 - 0.9999），检测限在1.4 - 2.8 ng/L范围内。日内和日间获得的相对标准偏差分别在2.8%至7.8%和3.1%至7.9%的范围内。所提出的方法成功应用于测定六个环境水样中的SAs，其中四个水样中可检测到SAs，浓度范围为10.5至120.2 ng/L。
