Cavellani Camila Lourencini, Gomes Nayara Cândida, de Melo e Silva Ana Teresa, Silva Renata Beatriz, Ferraz Mara Lúcia Fonseca, Faria Humberto Aparecido, Corrêa Rosana Rosa Miranda, Teixeira Vicente de Paula Antunes, Rocha Laura Penna
Department of Biological Sciences, General Pathology Division, Triângulo Mineiro Federal University, Uberaba, Minas Gerais State, Brazil.
J Int Assoc Provid AIDS Care. 2013 Sep-Oct;12(5):334-42. doi: 10.1177/2325957413488167. Epub 2013 May 15.
Studies have shown immunological and morphological alterations in the esophagus during the course of AIDS. Esophageal postmortem samples of 22 men with AIDS autopsied in a teaching hospital between 1982 and 2009 were collected. We carried out revision of the autopsy reports and medical records, morphometric analysis (Image J and KS-300 Kontron-Zeiss), and immunohistochemical (anti-S100, anti-IgA, anti-IgG, and anti-IgM) analysis of the esophagus. In accordance with most of the parameters evaluated, age and the smoking habit harmed the esophageal local immunity, whereas the use of antiretroviral therapy improved the immune characteristics of this organ. Patients with esophagitis also presented immunological fragility of the esophagus. This leads to the conclusion that alterations in the esophageal epithelium of patients with AIDS are not only caused by direct action of HIV but also the clinical and behavioral characteristics of the patient.
研究表明，在艾滋病病程中食管会出现免疫和形态学改变。收集了1982年至2009年间在一家教学医院进行尸检的22名艾滋病男性患者的食管尸检样本。我们对尸检报告和病历进行了复查，对食管进行了形态计量分析（Image J和KS - 300 Kontron - Zeiss）以及免疫组织化学分析（抗S100、抗IgA、抗IgG和抗IgM）。根据评估的大多数参数，年龄和吸烟习惯损害了食管局部免疫力，而抗逆转录病毒疗法的使用改善了该器官的免疫特征。食管炎患者也表现出食管的免疫脆弱性。由此得出结论，艾滋病患者食管上皮的改变不仅是由HIV的直接作用引起的，还与患者的临床和行为特征有关。
