General Pathology Division, Triangulo Mineiro Federal University, Uberaba, Minas Gerais, Brazil.
Ann Diagn Pathol. 2013 Feb;17(1):67-71. doi: 10.1016/j.anndiagpath.2012.06.006. Epub 2012 Aug 24.
Hair keeps the scalp warmer and slightly moister than the rest of the skin, which contributes to a favorable environment for mycotic, bacterial, and parasitic infections. It is well established that AIDS makes the patient more susceptible to opportunistic infections and cutaneous manifestations. Because of this, the aim of this study was to analyze scalp fragments of autopsied women with AIDS. Twenty-eight scalp samples of women aged between 18 and 46 years were observed. These women were divided into 2 groups: with AIDS (n = 14) and without AIDS (n = 14). We conducted histochemical (hematoxylin-eosin, Picrosirius, and Verhoeff), morphometric (Image J; National Institutes of Health, Hamilton, ON, Canada and KS-300 Kontron-Zeiss; Kontron Elektronik, Carl-Zeiss, Germany), and immunohistochemical (S-100) analyses of the scalp. In patients with AIDS, epithelial thickness, number of epithelial cell layers, number of immature Langerhans cells in the epidermis, and percentages of elastic fibers in the dermis were significantly lower, whereas telogen hair follicles were significantly higher. The percentage of collagen fibers in the dermis and the diameter of the epithelial cells were smaller in patients with AIDS, without significant difference. AIDS possibly causes immunologic and morphologic alterations in the scalp. This study may establish parameters for better clinical and morphologic diagnostic in patients with AIDS.
头发使头皮比皮肤的其他部位温暖且略湿润，这有助于真菌、细菌和寄生虫感染的有利环境。众所周知，艾滋病使患者更容易受到机会性感染和皮肤表现的影响。因此，本研究旨在分析艾滋病女性尸检头皮碎片。观察了 28 名年龄在 18 至 46 岁之间的女性头皮样本。这些女性分为两组：艾滋病组（n=14）和非艾滋病组（n=14）。我们进行了头皮的组织化学（苏木精-伊红、派罗斯红和维拉法）、形态计量学（Image J；加拿大安大略省汉密尔顿国立卫生研究院和 KS-300 康创-蔡司；德国卡尔蔡司康创电子）和免疫组织化学（S-100）分析。在艾滋病患者中，上皮厚度、上皮细胞层数、表皮不成熟朗格汉斯细胞数量和真皮弹性纤维百分比明显降低，而休止期毛囊明显增加。艾滋病患者真皮胶原纤维百分比和上皮细胞直径较小，但无显著差异。艾滋病可能导致头皮的免疫和形态改变。本研究可为艾滋病患者的临床和形态学诊断提供更好的参数。
