内皮祖细胞治疗糖尿病视网膜病变的前景。
Promise of endothelial progenitor cell for treatment of diabetic retinopathy.
作者信息
Bhatwadekar Ashay D, Shaw Lynn C, Grant Maria B
机构信息
Dept of Pharmacology and Therapeutics, University of Florida, 1600 SW Archer Road Gainesville, FL 32610-0267, USA Tel.: + 1 352 392 9006
出版信息
Expert Rev Endocrinol Metab. 2010 Jan;5(1):29-37. doi: 10.1586/eem.09.75.
Abstract
Progressive obliteration of the retinal microvessels is a characteristic of diabetic retinopathy. The resultant retinal ischemia leads to sight-threatening neovascularization and macular edema. Bone marrow-derived endothelial progenitor cells play a critical role in vascular maintenance and repair and forms the basis of cellular therapy for revascularization of ischemic myocardium and ischemic limbs. Emerging studies show potential of these cells in revascularization of ischemic retina and this review summarizes this possibility. We also report current pharmacological options to correct diabetes-associated defects in endothelial progenitor cells for their therapeutic transfer.
摘要
视网膜微血管的进行性闭塞是糖尿病视网膜病变的一个特征。由此产生的视网膜缺血会导致威胁视力的新生血管形成和黄斑水肿。骨髓来源的内皮祖细胞在血管维持和修复中起关键作用，并构成了用于缺血心肌和缺血肢体血管重建的细胞治疗的基础。新兴研究显示了这些细胞在缺血视网膜血管重建中的潜力，本综述总结了这种可能性。我们还报告了目前用于纠正内皮祖细胞中与糖尿病相关缺陷以便进行治疗性移植的药理学选择。
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本文引用的文献
1
Diabetic retinopathy is associated with bone marrow neuropathy and a depressed peripheral clock.
J Exp Med. 2009 Dec 21;206(13):2897-906. doi: 10.1084/jem.20090889. Epub 2009 Nov 23.
2
Circulating endothelial progenitor cells in malignant gliomas.
J Neurosurg. 2010 Jan;112(1):43-9. doi: 10.3171/2009.5.JNS081074.
3
Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment.
Nature. 2009 Jul 9;460(7252):259-63. doi: 10.1038/nature08099. Epub 2009 Jun 10.
4
Differentiation of bone marrow-derived endothelial progenitor cells is shifted into a proinflammatory phenotype by hyperglycemia.
Mol Med. 2009 May-Jun;15(5-6):152-9. doi: 10.2119/molmed.2009.00032. Epub 2009 Mar 11.
5
Oxidative stress impairs endothelial progenitor cell function.
Antioxid Redox Signal. 2008 Nov;10(11):1895-907. doi: 10.1089/ars.2008.2118.
6
Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosis.
Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E456-62. doi: 10.1152/ajpendo.00015.2008. Epub 2008 Jun 17.
7
Carbon monoxide and nitric oxide mediate cytoskeletal reorganization in microvascular cells via vasodilator-stimulated phosphoprotein phosphorylation: evidence for blunted responsiveness in diabetes.
Diabetes. 2008 Sep;57(9):2488-94. doi: 10.2337/db08-0381. Epub 2008 Jun 16.
8
Augmentation of vascular remodeling by uncoupled endothelial nitric oxide synthase in a mouse model of diabetes mellitus.
Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1068-76. doi: 10.1161/ATVBAHA.107.160754. Epub 2008 Apr 10.
9
Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy.
Invest Ophthalmol Vis Sci. 2007 Nov;48(11):5257-65. doi: 10.1167/iovs.07-0112.
10
Restoration of microvascular function in the infarct-related artery by intracoronary transplantation of bone marrow progenitor cells in patients with acute myocardial infarction: the Doppler Substudy of the Reinfusion of Enriched Progenitor Cells and Infarct Remodeling in Acute Myocardial Infarction (REPAIR-AMI) trial.
Circulation. 2007 Jul 24;116(4):366-74. doi: 10.1161/CIRCULATIONAHA.106.671545. Epub 2007 Jul 9.
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