Woradet Somkiattiyos, Promthet Supannee, Songserm Nopparat, Parkin Donald Maxwell
Department of Epidemiology, Faculty of Public Health, Khon Kaen University, Thailand.
Asian Pac J Cancer Prev. 2013;14(3):1623-7. doi: 10.7314/apjcp.2013.14.3.1623.
Cholangiocarcinoma (CCA) is a major health problem and cause of death among people in Northeastern Thailand. In this prospective study 171 patients newly diagnosed with CCA by physicians in 5 tertiary hospitals in four provinces of northeastern of Thailand between February and July 2011 were followed up to January 2012. The outcome was survival time from diagnosis to death. A total of 758.4 person-months of follow-up were available. The mortality rate was 16.9 per 100 person-months (95%CI: 14.1-20.1). The median survival time among CCA patients was 4.3 months (95%CI: 3.3-5.1). Cox's proportional hazard model was used to study the independent effects of factors affecting survival time among patients. Statistically significant factors included advanced stage at diagnosis (HR: 2.5, 95%CI: 1.7-3.8), presentation with jaundice (HR: 1.7, 95%CI: 1.1-2.4) or ascites (HR: 2.8, 95%CI: 1.8-4.4), and positive serum carcinoembryonic antigen (HR: 2.3, 95%CI: 1.2-4.3). Patients who had received standard treatment had a better prognosis that those who did not (HR: 0.5, 95%CI: 0.3-0.7).
胆管癌（CCA）是泰国东北部人群面临的一个主要健康问题及死亡原因。在这项前瞻性研究中，2011年2月至7月期间，泰国东北部四个省份的5家三级医院的医生新诊断出的171例CCA患者被随访至2012年1月。观察结果为从诊断到死亡的生存时间。总共获得了758.4人月的随访数据。死亡率为每100人月16.9例（95%置信区间：14.1 - 20.1）。CCA患者的中位生存时间为4.3个月（95%置信区间：3.3 - 5.1）。采用Cox比例风险模型研究影响患者生存时间的因素的独立作用。具有统计学意义的因素包括诊断时处于晚期（风险比：2.5，95%置信区间：1.7 - 3.
