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Predictors of the change in bilirubin levels over twelve weeks of treatment with atazanavir.阿扎那韦治疗十二周期间胆红素水平变化的预测因素。
AIDS Res Ther. 2013 May 16;10(1):13. doi: 10.1186/1742-6405-10-13.
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Early lipid changes with atazanavir/ritonavir or darunavir/ritonavir.阿扎那韦/利托那韦或达芦那韦/利托那韦引起的早期脂质变化。
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Bilirubin-a potential marker of drug exposure in atazanavir-based antiretroviral therapy.胆红素——基于阿扎那韦的抗逆转录病毒疗法中药物暴露的潜在标志物。
AAPS J. 2011 Dec;13(4):598-605. doi: 10.1208/s12248-011-9299-0. Epub 2011 Sep 13.
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Extended mathematical model for "in vivo" quantification of the interaction betweeen atazanavir and bilirubin.用于体内定量测定阿扎那韦与胆红素相互作用的扩展数学模型。
J Clin Pharmacol. 2014 Feb;54(2):161-7. doi: 10.1002/jcph.234. Epub 2013 Dec 2.
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External validation of the bilirubin-atazanavir nomogram for assessment of atazanavir plasma exposure in HIV-1-infected patients.评估 HIV-1 感染患者中阿扎那韦血浆暴露的胆红素-阿扎那韦列线图的外部验证。
AAPS J. 2013 Apr;15(2):308-15. doi: 10.1208/s12248-012-9440-8. Epub 2012 Dec 7.
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A cross-sectional study to evaluate second line virological failure and elevated bilirubin as a surrogate for adherence to atazanavir/ritonavir in two urban HIV clinics in Lilongwe, Malawi.一项横断面研究，旨在评估马拉维利隆圭两家城市艾滋病诊所中二线病毒学失败情况以及胆红素升高作为阿扎那韦/利托那韦依从性替代指标的情况。
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Association Between Atazanavir-Induced Hyperbilirubinemia and Cardiovascular Disease in Patients Infected with HIV.阿扎那韦诱导的高胆红素血症与 HIV 感染患者心血管疾病的关联。
J Am Heart Assoc. 2020 Oct 20;9(19):e016310. doi: 10.1161/JAHA.120.016310. Epub 2020 Sep 15.
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Conflicting effects of atazanavir therapy on atherosclerotic risk factors in stable HIV patients: A randomized trial of regimen switch to atazanavir.阿扎那韦治疗对稳定期HIV患者动脉粥样硬化危险因素的矛盾影响：一项转换为阿扎那韦治疗方案的随机试验
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9
Drug- and Drug Abuse-Associated Hyperbilirubinemia: Experience With Atazanavir.药物及药物滥用相关性高胆红素血症：阿扎那韦治疗经验。
Clin Pharmacol Drug Dev. 2017 Mar;6(2):140-146. doi: 10.1002/cpdd.314.
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Switching to unboosted atazanavir reduces bilirubin and triglycerides without compromising treatment efficacy in UGT1A1*28 polymorphism carriers.在 UGT1A1*28 多态性携带者中，转换为非强化阿扎那韦可降低胆红素和甘油三酯，而不影响治疗效果。
J Antimicrob Chemother. 2012 Sep;67(9):2236-42. doi: 10.1093/jac/dks175. Epub 2012 Jun 2.

引用本文的文献

1
Association Between Bilirubin, Atazanavir, and Cardiovascular Disease Events Among People Living With HIV Across the United States.在美国，胆红素、阿扎那韦与 HIV 感染者心血管疾病事件之间的关联。
J Acquir Immune Defic Syndr. 2019 Aug 15;81(5):e141-e147. doi: 10.1097/QAI.0000000000002071.

本文引用的文献

1
Mechanism of efavirenz influence on methadone pharmacokinetics and pharmacodynamics.依非韦伦对美沙酮药代动力学和药效学影响的作用机制。
Clin Pharmacol Ther. 2012 Apr;91(4):673-84. doi: 10.1038/clpt.2011.276. Epub 2012 Mar 7.
2
Atazanavir plasma concentrations are impaired in HIV-1-infected adults simultaneously taking a methadone oral solution in a once-daily observed therapy setting.在接受每日一次观察治疗的同时，接受美沙酮口服液的 HIV-1 感染成年人的阿扎那韦血浆浓度受损。
Eur J Clin Pharmacol. 2010 Apr;66(4):375-81. doi: 10.1007/s00228-009-0767-8. Epub 2009 Dec 24.
3
Gilbert's disease and atazanavir: from phenotype to UDP-glucuronosyltransferase haplotype.吉尔伯特综合征与阿扎那韦：从表型到尿苷二磷酸葡萄糖醛酸转移酶单倍型
Hepatology. 2006 Nov;44(5):1324-32. doi: 10.1002/hep.21361.
4
A single centre cohort experience with a new once daily antiretroviral drug.一项关于新型每日一次抗逆转录病毒药物的单中心队列研究经验。
Postgrad Med J. 2006 May;82(967):343-6. doi: 10.1136/pgmj.2006.044867.
5
Gilbert syndrome and the development of antiretroviral therapy-associated hyperbilirubinemia.吉尔伯特综合征与抗逆转录病毒疗法相关高胆红素血症的发生
J Infect Dis. 2005 Oct 15;192(8):1381-6. doi: 10.1086/466531. Epub 2005 Sep 9.
6
In vitro inhibition of UDP glucuronosyltransferases by atazanavir and other HIV protease inhibitors and the relationship of this property to in vivo bilirubin glucuronidation.阿扎那韦及其他HIV蛋白酶抑制剂对尿苷二磷酸葡萄糖醛酸基转移酶的体外抑制作用及其该特性与体内胆红素葡萄糖醛酸化的关系。
Drug Metab Dispos. 2005 Nov;33(11):1729-39. doi: 10.1124/dmd.105.005447. Epub 2005 Aug 23.
7
Interactions between atazanavir-ritonavir and tenofovir in heavily pretreated human immunodeficiency virus-infected patients.阿扎那韦-利托那韦与替诺福韦在接受过大量治疗的人类免疫缺陷病毒感染患者中的相互作用。
Antimicrob Agents Chemother. 2004 Jun;48(6):2091-6. doi: 10.1128/AAC.48.6.2091-2096.2004.
8
Drug-induced liver injury associated with antiretroviral therapy that includes HIV-1 protease inhibitors.与包括HIV-1蛋白酶抑制剂在内的抗逆转录病毒疗法相关的药物性肝损伤。
Clin Infect Dis. 2004 Mar 1;38 Suppl 2:S90-7. doi: 10.1086/381444.
9
Incidence of and risk factors for severe hepatotoxicity associated with antiretroviral combination therapy.抗逆转录病毒联合疗法相关严重肝毒性的发生率及危险因素。
J Infect Dis. 2002 Jul 1;186(1):23-31. doi: 10.1086/341084. Epub 2002 Jun 14.
10
Mechanism of indinavir-induced hyperbilirubinemia.茚地那韦诱导高胆红素血症的机制。
Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12671-6. doi: 10.1073/pnas.231140698. Epub 2001 Oct 16.

Predictors of the change in bilirubin levels over twelve weeks of treatment with atazanavir.

作者信息

Cotter Aoife G, Brown Aisling, Sheehan Gerard, Lambert John, Sabin Caroline A, Mallon Patrick Wg

机构信息

HIV Molecular Research Group, School of Medicine & Medical Science, University College Dublin, Dublin, Ireland.

出版信息

AIDS Res Ther. 2013 May 16;10(1):13. doi: 10.1186/1742-6405-10-13.

DOI:10.1186/1742-6405-10-13
PMID:23680529
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3658904/
Abstract
摘要