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[全科医疗中的乳腺炎。细菌学检查有用吗?]

[Mastitis in general practice. Is bacteriologic examination useful?].

作者信息

Aabø O, Matheson I, Aursnes I, Horgen M, Lagerløv P, Melby K

机构信息

Furuset Helsesenter, Oslo.

出版信息

Tidsskr Nor Laegeforen. 1990 Jun 20;110(16):2075-7.

PMID:2368071
Abstract

For a period of 22 months, postpartial women in Oslo were asked to consult one of several specific general practitioners in the event of mastitis. Clinical symptoms, bacteriological findings in breast milk and treatment were recorded in 43 patients. Patients with a favourable (n = 35) and with an unfavourable outcome (n = 8) defined as abscess, relapse and/or relief of symptoms after more than seven days, were compared. Unfavourable outcome was characterized by higher score of clinical symptoms and a higher isolation frequency of Staphylococcus aureus. The occurrence of fever did not differ between the groups. Bacteriological findings in milk from both breasts were compared with the findings from 100 milk donors. Staphylococcus aureus was more frequently isolated in milk from affected breasts than from unaffected and control breasts (17/40 versus 4/40 versus 4/100). Most of the Staphylococcus aureus strains (70%) were betalactamase producers. Coagulase negative staphylococci were a frequent finding in all milk samples, whereas Gram-negative bacteria were frequent only in the controls. The presence of pathogenic bacteria, as well as high bacterial counts, were associated with a higher number of symptoms. However, the predictive value of the bacteriological examination was low. Our study indicates that bacteriological examination of breast milk is justified only in patients with severe, acute symptoms and recurrences when betalactamase producing Staphylococcus aureus are suspected.

摘要

在22个月的时间里,奥斯陆接受过乳房部分切除术的女性被要求在发生乳腺炎时咨询几位特定的全科医生之一。记录了43例患者的临床症状、母乳中的细菌学检查结果及治疗情况。对转归良好(n = 35)和转归不良(n = 8,定义为出现脓肿、复发和/或症状缓解超过7天)的患者进行了比较。转归不良的特点是临床症状评分较高,金黄色葡萄球菌的分离频率较高。两组之间发热的发生率没有差异。将双侧乳房乳汁的细菌学检查结果与100名乳汁捐赠者的检查结果进行了比较。与未受影响的乳房及对照乳房的乳汁相比,受影响乳房的乳汁中更常分离出金黄色葡萄球菌(17/40对4/40对4/100)。大多数金黄色葡萄球菌菌株(70%)是β-内酰胺酶产生菌。凝固酶阴性葡萄球菌在所有乳汁样本中都很常见,而革兰氏阴性菌仅在对照样本中常见。病原菌的存在以及高细菌计数与更多的症状相关。然而,细菌学检查的预测价值较低。我们的研究表明,仅在怀疑有产β-内酰胺酶金黄色葡萄球菌感染且出现严重急性症状和复发的患者中,对母乳进行细菌学检查才是合理的。

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