Wheless James W, Almoazen Hassan
Division of Pediatric Neurology, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38105, USA.
J Child Neurol. 2013 Jul;28(7):933-6. doi: 10.1177/0883073813488664. Epub 2013 May 16.
Facial angiofibromas are dermatological manifestations of tuberous sclerosis complex, a neurocutaneous disorder characterized by excess cell growth and proliferation. Oral rapamycin has been used to treat visceral tuberous sclerosis-related tumors; however, the side effect profile of this medicine precludes its routine use in patients lacking significant internal involvement. The authors formulated a novel rapamycin cream that is easy to compound and apply, does not cause local or systemic side effects, and results in a dramatic improvement of facial angiofibromas.
面部血管纤维瘤是结节性硬化症的皮肤表现，结节性硬化症是一种神经皮肤疾病，其特征是细胞过度生长和增殖。口服雷帕霉素已被用于治疗与内脏结节性硬化症相关的肿瘤；然而，这种药物的副作用限制了它在没有严重内部受累患者中的常规使用。作者配制了一种新型雷帕霉素乳膏，它易于配制和应用，不会引起局部或全身副作用，并且能显著改善面部血管纤维瘤。
