Tiedemann Svendsen Mathias, Bygum Anette, Hansen Lars Kjærsgaard, Broesby-Olsen Sigurd
Hudafdeling I og Allergicenter, Odense Universitetshospital, Sdr. Boulevard 29, 5000 Odense C.
Ugeskr Laeger. 2013 Oct 21;175(43):2569-70.
We present a five-year-old boy with facial angiofibromas associated to tuberous sclerosis successfully treated with topical sirolimus 0.4% applied three times a week for six months. After six months we observed a nearly complete resolution of facial angiofibromas. The blood levels of sirolimus remained under a detectable limit and no side-effects were observed. Topically applied sirolimus seems to be a safe and effective alternative to surgery or laser therapy.
我们报告一名患有与结节性硬化症相关的面部血管纤维瘤的五岁男孩，通过每周三次外用0.4%西罗莫司，持续六个月成功治愈。六个月后，我们观察到面部血管纤维瘤几乎完全消退。西罗莫司的血药浓度仍低于可检测水平，且未观察到副作用。外用西罗莫司似乎是手术或激光治疗的一种安全有效的替代方法。
