Nationwide Children's Hospital, The Ohio State University School of Medicine, 700 Children's Drive, Columbus, OH 43205, USA.
Curr Allergy Asthma Rep. 2013 Aug;13(4):347-53. doi: 10.1007/s11882-013-0352-1.
Celiac disease (CD) is an autoimmune condition affecting the small intestine, triggered by the ingestion of gluten, the protein fraction of wheat, barley, and rye. There is a strong linkage between CD and HLA-DQ2 and HLA-DQ8 haplotypes. Multiple case reports and small series suggest concordance between CD and other autoimmune disorders. This paper provides a brief overview of the pathogenesis of CD and reviews the literature regarding associations between CD and other autoimmune diseases, including the potential effects of gluten-free diet therapy on the prevention or amelioration of associated diseases.
乳糜泻(CD)是一种影响小肠的自身免疫性疾病,由摄入小麦、大麦和黑麦中的蛋白质成分——麸质所触发。CD 与 HLA-DQ2 和 HLA-DQ8 单体型之间存在强烈的关联性。多个病例报告和小系列研究表明 CD 与其他自身免疫性疾病之间存在一致性。本文简要概述了 CD 的发病机制,并回顾了有关 CD 与其他自身免疫性疾病之间关联的文献,包括无麸质饮食疗法对预防或改善相关疾病的潜在影响。