Poovorawan Yong, Chongsrisawat Voranush, Shafi Fakrudeen, Boudville Irving, Liu Yanfang, Hutagalung Yanee, Bock Hans L
Chulalongkorn University Hospital, Bangkok, Thailand.
Southeast Asian J Trop Med Public Health. 2013 Jan;44(1):50-3.
We conducted a hospital-based study from June 2002 to December 2006 of Thai children aged 1-15 years with acute hepatic failure (AHF) to determine the causes and outcomes. Eleven children were included in the study. Hepatitis B virus was the cause of AHF in one child, infection-associated hemophagocytic syndrome was the cause in 1 child, Wilson's disease was the cause in 1 child and dengue fever was suspected to be the cause in 2 children. In 6 children the cause of AHF was unknown. Jaundice was reported in 9 of 11 children. Ten of 11 children had mild to moderate encephalopathy on admission. Five of 11 children died due to AHF. No liver transplantations were performed among the children in this study. Further studies into the relationship between dengue infection and AHF are needed.
我们于2002年6月至2006年12月对1至15岁患有急性肝衰竭（AHF）的泰国儿童进行了一项基于医院的研究，以确定病因和预后情况。该研究纳入了11名儿童。1名儿童的急性肝衰竭病因是乙型肝炎病毒，1名儿童是感染相关噬血细胞综合征，1名儿童是威尔逊病，2名儿童疑似病因是登革热。6名儿童的急性肝衰竭病因不明。11名儿童中有9名出现黄疸。11名儿童中有10名入院时患有轻度至中度脑病。11名儿童中有5名因急性肝衰竭死亡。本研究中的儿童均未接受肝移植。需要进一步研究登革热感染与急性肝衰竭之间的关系。
